Christensen Amalie, West Ann-Katrine Vrans, Wullkopf Lena, Terra Erler Janine, Oddershede Lene Broeng, Mathiesen Joachim
Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.
Phys Biol. 2018 Jul 25;15(6):066004. doi: 10.1088/1478-3975/aacedc.
Mechanical forces are important factors in the development, coordination and collective motion of cells. Based on a continuum-scale model, we consider the influence of substrate friction on cell motility in confluent living tissue. We test our model on the experimental data of endothelial and cancer cells. In contrast to the commonly used drag friction, we find that solid friction best captures the cell speed distribution. From our model, we quantify a number of measurable physical tissue parameters, such as the ratio between the viscosity and substrate friction.
机械力是细胞发育、协调和集体运动的重要因素。基于连续介质尺度模型，我们考虑了底物摩擦对汇合活组织中细胞运动的影响。我们根据内皮细胞和癌细胞的实验数据对模型进行了测试。与常用的拖曳摩擦不同，我们发现固体摩擦最能体现细胞速度分布。通过我们的模型，我们量化了一些可测量的物理组织参数，如粘度与底物摩擦之间的比率。
