IEEE Trans Med Imaging. 2019 Jan;38(1):107-112. doi: 10.1109/TMI.2018.2856857. Epub 2018 Jul 17.
We measured the reduction of speckle by frequency compounding using Gaussian pulses, which have the least time-bandwidth product. The experimental results obtained from a tissue mimicking phantom agree quantitatively with numerical simulations of randomly distributed point scatterers. For a fixed axial resolution, the amount of speckle reduction is found to approach a maximum as the number of bands increases while the total spectral range that they cover is kept constant. An analytical solution of the maximal speckle reduction is derived and shows that the maximum improves approximately as the inverse square root of the Gaussian pulse bandwidth. Since the axial resolution is proportional to the inverse of the pulse bandwidth, an optimized trade-off between speckle reduction and axial resolution is obtained. Considerations for the applications of the optimized trade-off are discussed.
我们使用具有最小时间带宽积的高斯脉冲来测量频率复合对散斑的减少。从组织模拟体模获得的实验结果与随机分布点散射体的数值模拟定量吻合。对于固定的轴向分辨率,当增加带的数量而保持它们覆盖的总光谱范围恒定时,发现散斑减少的量接近最大值。推导了最大散斑减少的解析解,并表明最大值大约随高斯脉冲带宽的倒数平方根而提高。由于轴向分辨率与脉冲带宽的倒数成正比,因此在散斑减少和轴向分辨率之间获得了优化的权衡。讨论了优化权衡的应用考虑因素。