姜黄素与可生物降解膜促进成年大鼠坐骨神经横断后神经再生及功能恢复
Curcumin and Biodegradable Membrane Promote Nerve Regeneration and Functional Recovery After Sciatic Nerve Transection in Adult Rats.
作者信息
Moattari Mehrnaz, Moattari Farahnaz, Kouchesfahani Homa Mohseni, Kaka Gholamreza, Sadraie Seyed Homayoon, Naghdi Majid, Mansouri Korosh
机构信息
Faculty of Agriculture and Natural Resources, Persian Gulf University, Bushehr.
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran.
出版信息
Ann Plast Surg. 2018 Sep;81(3):335-339. doi: 10.1097/SAP.0000000000001566.
BACKGROUND
Curcumin has immunomodulatory anti-inflammatory, antioxidant, and neuroprotective properties. The goal of this study was to determine the effects of curcumin and biodegradable membrane on nerve healing in rat sciatic nerve transected injuries.
METHODS
Rats were divided into groups: (1) control group (Ctrl), (2) curcumin group (Cur), (3) membrane group (Mem), and (4) membrane and curcumin group (Mem + Cur). Functional recovery was evaluated at 2, 4, 6, and 8 weeks after surgery. At the end of the eighth week after surgery, histological assessments were done.
RESULTS
At the end of 8th week after surgery, functional assessments (sciatic nerve index, withdrawal reflex latency, and electromyography) in the Mem + Cur group improved compared with other groups (P < 0.05). Histological results (number of nerve fibers, diameter of nerve fibers, and myelin thickness) improved in the Mem + Cur group compared with the control, Cur, and Mem groups (P < 0.05).
CONCLUSION
The present study showed the positive effects of Mem + Cur on nerve regeneration of transected sciatic nerve in rat model.
背景
姜黄素具有免疫调节、抗炎、抗氧化和神经保护特性。本研究的目的是确定姜黄素和可生物降解膜对大鼠坐骨神经横断损伤神经愈合的影响。
方法
将大鼠分为几组：（1）对照组（Ctrl），（2）姜黄素组（Cur），（3）膜组（Mem），以及（4）膜和姜黄素组（Mem + Cur）。在术后2、4、6和8周评估功能恢复情况。在术后第八周结束时，进行组织学评估。
结果
术后第8周结束时，Mem + Cur组的功能评估（坐骨神经指数、退缩反射潜伏期和肌电图）与其他组相比有所改善（P < 0.05）。与对照组、Cur组和Mem组相比，Mem + Cur组的组织学结果（神经纤维数量、神经纤维直径和髓鞘厚度）有所改善（P < 0.05）。
结论
本研究表明Mem + Cur对大鼠模型中横断坐骨神经的神经再生具有积极作用。
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