Ge Xuemei, Wu Shang, Shen Wen, Chen Lijuan, Zheng Yan, Ao Fen, Ning Yuanlan, Mao Yueyang, Chen Zhong
Department of Food Science and Technology, College of Light Industry Science and Engineering, Nanjing Forestry University, Nanjing 210037, China.
School of Food and Bioengineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Bioengineering (Basel). 2022 Mar 24;9(4):130. doi: 10.3390/bioengineering9040130.
In this work, gold nanoparticles (AuNPs) and curcumin drug were incorporated in polyvinylidene fluoride (PVDF) nanofibers by electrospinning as a novel tissue engineering scaffold in nerve regeneration. The influence of AuNPs on the morphology, crystallinity, and drug release behavior of nanofiber membranes was characterized. A successful composite nanofiber membrane sample was observed by scanning electron microscopy (SEM). The addition of AuNPs showed the improved as well as prolonged cumulative release of the drug. The results indicated that PVDF-AuNPs nanofiber membrane could potentially be applied for nerve regeneration.
在本研究中，通过静电纺丝将金纳米颗粒（AuNPs）和姜黄素药物掺入聚偏氟乙烯（PVDF）纳米纤维中，作为用于神经再生的新型组织工程支架。表征了AuNPs对纳米纤维膜的形态、结晶度和药物释放行为的影响。通过扫描电子显微镜（SEM）观察到成功的复合纳米纤维膜样品。AuNPs的添加显示出药物累积释放的改善和延长。结果表明，PVDF-AuNPs纳米纤维膜有可能应用于神经再生。
