Palmer R M, Lucas R B, Langdon J D
Histopathology. 1985 Oct;9(10):1061-76. doi: 10.1111/j.1365-2559.1985.tb02785.x.
Previous ultrastructural studies of pleomorphic adenoma have presented conflicting results with regard to the role of myoepithelial cells in the histogenesis of this tumour. In the present study specimens of ten major salivary gland pleomorphic adenomas were examined ultrastructurally and a number of cell types identified. The material was subjected to quantification using the stereological method of point counting. The results showed a wide spectrum of differentiation within these tumours in which typical myoepithelial cells were rarely encountered even in situations where they are reported to occur in routine histological preparations. Cells with some myoepithelial features were more numerous but duct cells accounted for the majority of tumour cells. The ultrastructural findings correlated well with previously reported immunocytochemical data and further support certain ideas about salivary gland tumour histogenesis.
以往关于多形性腺瘤的超微结构研究，在肌上皮细胞在该肿瘤组织发生中的作用方面给出了相互矛盾的结果。在本研究中，对10例主要涎腺多形性腺瘤标本进行了超微结构检查，并识别出多种细胞类型。采用点计数的体视学方法对材料进行了定量分析。结果显示，这些肿瘤内存在广泛的分化谱，即使在常规组织学切片中据报道有典型肌上皮细胞出现的情况下，也很少能见到它们。具有一些肌上皮特征的细胞数量较多，但导管细胞占肿瘤细胞的大多数。超微结构研究结果与先前报道的免疫细胞化学数据高度相关，并进一步支持了有关涎腺肿瘤组织发生的某些观点。
