Govind Babu K, Anand Abhishek, Lakshmaiah Kuntegowdanahalli C, Lokanatha Dasappa, Jacob Linu Abraham, Suresh Babu M C, Lokesh Kadabur N, Rudresha Haleshappa A, Rajeev Lakkavalli K, Saldanha Smitha C, Giri G V, R Chethan, Koppaka Deepak, Panwar Dipti, Kumar Rekha V
Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru 560029, India.
Department of Pathology, Kidwai Cancer Institute, Bengaluru 560029, India.
Ecancermedicalscience. 2018 Jun 26;12:845. doi: 10.3332/ecancer.2018.845. eCollection 2018.
Breast cancer is a heterogeneous disease which is divided broadly into luminal, HER2 and basal type based on molecular profiling. Increased body mass index (BMI) has been associated with the risk of developing breast cancer but the association based on molecular subtype remains conflicting.
This was an observational study carried out over a period of 2 years. Nonmetastatic breast cancer patients were evaluated for the tumour subtype based on surrogate markers (ER, PR and HER2). The BMI of these patients was correlated with the tumour subtype and size.
We studied 476 patients with breast cancer with the median age of 46 years (range, 25-86) and 58% were premenopausal. The mean BMI of the cohort was 24.1, which was significantly higher in postmenopausal women (24.9 versus 23.6, < 0.05). Overall, only 10% of patients were obese. The mean BMI in the luminal, HER2 and TNBC subtypes was 24.7, 22.4 and 23.9, respectively ( < 0.01). Also, the mean tumour size in luminal, HER2 and TNBC subtype was 4.02, 3.80 and 4.27 cm, respectively ( = 0.158).
The average BMI was higher in patients with luminal subtype followed by TNBC and lowest for HER2 at the time of diagnosis. The mean tumour size was numerically higher for TNBC and lowest for HER2 subtype although the difference was not statistically significant. Larger studies may provide clarity of association between the BMI and tumour subtype.
乳腺癌是一种异质性疾病，根据分子特征大致分为管腔型、HER2型和基底型。体重指数（BMI）升高与患乳腺癌的风险相关，但基于分子亚型的关联仍存在争议。
这是一项为期2年的观察性研究。根据替代标志物（雌激素受体、孕激素受体和HER2）对非转移性乳腺癌患者的肿瘤亚型进行评估。这些患者的BMI与肿瘤亚型和大小相关。
我们研究了476例乳腺癌患者，中位年龄为46岁（范围25 - 86岁），58%为绝经前患者。队列的平均BMI为24.1，绝经后女性显著更高（24.9对23.6，<0.05）。总体而言，只有10%的患者肥胖。管腔型、HER2型和三阴性乳腺癌（TNBC）亚型的平均BMI分别为24.7、22.4和23.9（<0.01）。此外，管腔型、HER2型和TNBC亚型的平均肿瘤大小分别为4.02、3.80和4.27厘米（P = 0.158）。
诊断时，管腔型亚型患者的平均BMI最高，其次是TNBC，HER2型最低。TNBC的平均肿瘤大小在数值上高于HER2亚型，尽管差异无统计学意义。更大规模的研究可能会明确BMI与肿瘤亚型之间的关联。
