Morais Junior Gilberto Santos, Rodrigues Nathalia Oliveira, Henriques Adriane Dallanora, Tonet-Furioso Audrey Cecília, Brito Ciro José, Gomes Lucy Oliveira, Moraes Clayton Franco, Nóbrega Otávio Toledo
Universidade de Brasília, 70910-900 Brasília, DF, Brazil.
Universidade Católica de Brasília, 71966-700 Águas Claras, DF, Brazil.
J Aging Res. 2018 Jun 21;2018:1475890. doi: 10.1155/2018/1475890. eCollection 2018.
Due to the high incidence of vascular diseases, it is necessary to identify new circulating or structural markers for predicting risk for chronic diseases. Some studies suggest that MMP1 gene polymorphisms are associated with the enzyme expression levels in situ (e.g., in atherosclerotic plaques).
Thus, the study of this polymorphism may help understanding the pathophysiology of coronary disease.
We performed cross-sectional clinical and laboratory evaluations (including measurement of intima-media thickness of carotid arteries) and genotyping of the MMP1 SNP rs495366 (A/G) in 366 elderly people.
No significant differences between genotypes were noted for biochemical, metabolic, inflammatory, or clinical variables except for a significant difference in intima-media thickness for the left carotid artery and a trend toward significance for the right counterpart.
Carriers of the allele associated with lower MMP1 expression (allele A) presented greater carotid thickness. We suggest that the phenomenon can be explained by impaired remodeling of the arterial wall (poor degradation of collagen fibers in this scenario), yielding carotid wall thickening and a greater intrinsic risk for cerebrovascular events.
由于血管疾病的高发病率，有必要确定新的循环或结构标志物以预测慢性病风险。一些研究表明，MMP1基因多态性与原位酶表达水平相关（如在动脉粥样硬化斑块中）。
因此，对这种多态性的研究可能有助于理解冠心病的病理生理学。
我们对366名老年人进行了横断面临床和实验室评估（包括测量颈动脉内膜中层厚度）以及MMP1单核苷酸多态性rs495366（A/G）基因分型。
除左颈动脉内膜中层厚度存在显著差异以及右颈动脉有显著性趋势外，各基因型在生化、代谢、炎症或临床变量方面未观察到显著差异。
与较低MMP1表达相关的等位基因（等位基因A）携带者的颈动脉厚度更大。我们认为这种现象可通过动脉壁重塑受损（在这种情况下胶原纤维降解不良）来解释，从而导致颈动脉壁增厚以及脑血管事件的内在风险增加。
