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盆腔放疗后的泌尿系统并发症

Urologic Complications Following Pelvic Radiotherapy.

作者信息

Lobo Niyati, Kulkarni Meghana, Hughes Simon, Nair Rajesh, Khan Muhammad Shamim, Thurairaja Ramesh

机构信息

Department of Urology, Guy's Hospital, London, United Kingdom.

Department of Oncology, Guy's Hospital, London, United Kingdom.

出版信息

Urology. 2018 Dec;122:1-9. doi: 10.1016/j.urology.2018.07.017. Epub 2018 Jul 20.

Abstract

Radiotherapy is widely used as a curative treatment for pelvic malignancies. The location of these organs leads to unavoidable exposure of the bladder, urethra, and distal ureters to radiation and may cause subsequent development of radiation cystitis, fistulae, strictures, and secondary malignancy. As cancer survival improves, an ever-increasing number of patients is living with the long-term complications of radiotherapy. Symptoms are not only debilitating for the patient but also pose a treatment challenge to the urologist. This review provides a comprehensive overview of the pathophysiology, clinical presentation, and current management strategies for the urologic complications following pelvic radiotherapy.

摘要

放射疗法被广泛用作盆腔恶性肿瘤的根治性治疗方法。这些器官的位置导致膀胱、尿道和输尿管远端不可避免地受到辐射,可能会引发放射性膀胱炎、瘘管、狭窄和继发性恶性肿瘤。随着癌症生存率的提高,越来越多的患者正承受着放射治疗的长期并发症。这些症状不仅使患者虚弱,也给泌尿科医生带来了治疗挑战。本综述全面概述了盆腔放疗后泌尿系统并发症的病理生理学、临床表现和当前的管理策略。

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