Liao Wan-Ting, Chiang Jen-Huai, Li Chia-Jung, Lee Ming-Tsung, Su Cheng-Chiung, Yen Hung-Rong
Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404 Taiwan.
Department of Chinese Medicine, Show Chwan Memorial Hospital, Changhua 500, Taiwan.
J Clin Med. 2018 Jul 22;7(7):179. doi: 10.3390/jcm7070179.
Polycystic ovary syndrome (PCOS) is a common condition, affecting 5⁻10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all its symptoms. Existing pharmaceutical agents, such as oral contraceptives (OCs), are suggested as a first-line therapy for menstrual irregularities; however, OCs are not appropriate for women pursuing pregnancy. Additionally, insulin-sensitizing agents, which appear to decrease insulin levels and hyperandrogenemia in women with PCOS, have been associated with a high incidence of gastrointestinal adverse effects. It is a common practice in Chinese society to receive traditional Chinese medicine (TCM) for treatment of gynecological problems and infertility. Current research demonstrates that several herbs and herbal formulas show beneficial effects in PCOS treatment. In this study, we conducted the first large-scale survey through the Taiwan National Health Insurance Program database to analyze TCM utilization patterns among women with PCOS in Taiwan during 1997⁻2010. The survey results revealed that 89.22% women with newly diagnosed PCOS had received TCM therapy. Jia-Wei-Xiao-Yao-San and Xiang-Fu (Rhizoma Cyperi) were the most commonly used formula and single herb, respectively, in the database. In addition, we found that the top five commonly prescribed single herbs and herbal formulas have shown promise in treating symptoms associated with PCOS.
多囊卵巢综合征（PCOS）是一种常见病症，影响着全球5%至10%的育龄女性。它具有严重的生殖方面影响，并会引发情绪障碍和代谢紊乱，如2型糖尿病。由于PCOS反映出多种异常情况，不存在单一药物能够治疗其所有症状。现有的药物制剂，如口服避孕药（OCs），被建议作为月经不调的一线治疗方法；然而，OCs并不适合有怀孕需求的女性。此外，胰岛素增敏剂似乎能降低PCOS女性的胰岛素水平和高雄激素血症，但却与胃肠道不良反应的高发生率相关。在中国社会，接受中医（TCM）治疗妇科问题和不孕症是一种常见做法。当前研究表明，几种草药和中药配方在PCOS治疗中显示出有益效果。在本研究中，我们通过台湾国民健康保险计划数据库进行了首次大规模调查，以分析1997年至2010年期间台湾PCOS女性的中医使用模式。调查结果显示，89.22%新诊断为PCOS的女性接受过中医治疗。在数据库中，加味逍遥散和香附（香附）分别是最常用的配方和单味药。此外，我们发现最常开具的前五种单味药和中药配方在治疗与PCOS相关的症状方面显示出前景。
