Wendling F, Varlet P, Charon M, Tambourin P
Virology. 1986 Mar;149(2):242-6. doi: 10.1016/0042-6822(86)90125-x.
A novel murine retrovirus complex was derived from the in vivo passage of a molecularly cloned Friend ecotropic helper virus. The virus isolate, myeloproliferative leukemia virus (MPLV), causes an acute (2-3 weeks) and generalized myeloproliferative disorder in adult mice. All strains of mice examined, including the C57BL/6J strain, developed the acute syndrome. This syndrome is characterized by a rapid hepatosplenomegaly, no thymus or lymph node involvement, granulocytosis, thrombocytosis, and erythroblastosis leading to polycythemia. The most prominent feature at the terminal phase of the disease is a granulocytic hyperplasia. The MPLV isolate replicates in vitro on NIH 3T3 fibroblasts but does not induce foci of transformed cells. Thus, MPLV exhibits unique biological properties that distinguish it either from the Friend virus complexes or from acutely transforming sarcomatogenic murine retrovirus which also induced a rapid splenomegaly.
一种新型鼠逆转录病毒复合体源自分子克隆的弗氏嗜亲性辅助病毒的体内传代。该病毒分离株，即骨髓增殖性白血病病毒（MPLV），可在成年小鼠中引发急性（2 - 3周）全身性骨髓增殖性疾病。所有检测的小鼠品系，包括C57BL/6J品系，都会出现急性综合征。该综合征的特征为迅速出现肝脾肿大，无胸腺或淋巴结受累，粒细胞增多、血小板增多以及成红细胞增多导致红细胞增多症。疾病终末期最显著的特征是粒细胞增生。MPLV分离株可在体外NIH 3T3成纤维细胞上复制，但不会诱导转化细胞灶形成。因此，MPLV展现出独特的生物学特性，使其有别于弗氏病毒复合体或同样能诱导迅速脾肿大的急性转化性肉瘤生成性鼠逆转录病毒。
