Gross G
Z Hautkr. 1985 Dec 1;60(23):1872-7.
The relationship between virus infections of the skin and mucosae and the development of malignant tumors is discussed. Guided by seroepidemiological data, virus infections with herpes simplex have been associated with the development of cervical carcinoma, genomes specific for HSV, however, have only occasionally been detected in malignant tumor tissue from the cervix. In contrast, DNA specific for papilloma virus could be identified to a high percentage in cervical cancerous and precancerous tissue as well as in bowenoid papulosis in both sexes. Aside from oncogenic papilloma virus, malignant degeneration seems to be dependent on both endogenic cofactors such as immunodeficiency and exogenic cofactors like sunlight or additional virus infections.
本文讨论了皮肤和黏膜病毒感染与恶性肿瘤发生之间的关系。在血清流行病学数据的指导下，单纯疱疹病毒感染已被认为与宫颈癌的发生有关，然而，仅偶尔在宫颈癌组织中检测到HSV特异性基因组。相比之下，在宫颈癌及癌前组织以及男女两性的鲍温样丘疹病中，可高比例鉴定出乳头瘤病毒特异性DNA。除致癌乳头瘤病毒外，恶性病变似乎取决于内源性辅助因素，如免疫缺陷，以及外源性辅助因素，如阳光或其他病毒感染。
