Prasad K S, Chitnis S N
Biochem Biophys Res Commun. 1986 Jan 14;134(1):338-43. doi: 10.1016/0006-291x(86)90568-1.
Rifampicin, but not chloramphenicol or other inhibitors of translation, inhibited EDTA-induced autolysis in Escherichia coli. Inhibition of EDTA-induced autolysis in E. coli was also observed with nalidixic acid and novobiocin, inhibitors of topoisomerase II. Rifampicin or nalidixic acid-resistant mutants of E. coli were resistant to the inhibitory effect of the respective antibiotic on EDTA-induced autolysis. The implications of these studies in regard to our understanding of the regulation of autolysis in E. coli are discussed.
利福平可抑制大肠杆菌中由乙二胺四乙酸（EDTA）诱导的自溶，但氯霉素或其他翻译抑制剂则无此作用。拓扑异构酶II抑制剂萘啶酸和新生霉素也可抑制大肠杆菌中由EDTA诱导的自溶。大肠杆菌的利福平或萘啶酸抗性突变体对相应抗生素对EDTA诱导自溶的抑制作用具有抗性。本文讨论了这些研究对于我们理解大肠杆菌自溶调控的意义。
