Chojnacki C, Kaczka A, Gasiorowska A, Fichna J, Chojnacki J, Brzozowski T
Department of Clinical Nutrition and Gastroenterological Diagnostic, Medical University, Lodz, Poland.
Department of Gastroenterology, Medical University, Lodz, Poland.
J Physiol Pharmacol. 2018 Apr;69(2). doi: 10.26402/jpp.2018.2.15. Epub 2018 Jul 23.
Different psychosomatic disorders are observed in postmenopausal women. The decrease of estrogen production is believed to be the main cause of their severity. It is nowadays evident that the decreased melatonin release in women at this age who suffer from postmenopausal disorders might also contribute to the severity of the symptoms. The aim of the study was to evaluate the effect of melatonin supplementation on female hormones release and the alteration in climacteric symptoms. The study included 60 postmenopausal women, aged 51 - 64 years, who were randomly allotted into two equal groups. Group I was recommended placebo (2 x 1 tablet) and Group II - melatonin (3 mg in the morning and 5 mg at bedtime) for 12 months. Serum levels of 17β-estradiol, follicle-stimulating hormone (FSH), melatonin and urinary 6-sulfatoxymelatonin (aMT6s) excretion as well as Kupperman Index (KI) and body mass index (BMI) were determined before the start and at 12 months after placebo or melatonin administration. In Group I only the value of KI slightly decreased (28.4 ± 2.9 versus 25.6 ± 3.8 points, P = 0,0619). In Group II - KI decreased from 29.1 ± 2.9 to 19.7 ± 3.1 points (P < 0.001) and BMI from 30.9 ± 2.9 to 28.1 ± 2.3 kg/m (P < 0.05). Melatonin supplementation failed to change significantly the serum concentration of female reproductive hormones 17β-estradiol and FSH. We conclude that melatonin supplementation therapy exerts a positive effect on psychosomatic symptoms in postmenopausal women and can be recommended as the useful adjuvant therapeutic option in treatment of these disorders.
绝经后女性会出现不同的身心失调症状。雌激素分泌减少被认为是症状严重程度的主要原因。如今很明显，患有绝经后失调的这个年龄段女性体内褪黑素分泌减少也可能导致症状加重。本研究的目的是评估补充褪黑素对女性激素释放及更年期症状变化的影响。该研究纳入了60名年龄在51 - 64岁的绝经后女性，她们被随机分为两组，每组人数相等。第一组服用安慰剂（每日2次，每次1片），第二组服用褪黑素（早上3毫克，睡前5毫克），为期12个月。在服用安慰剂或褪黑素之前及服用12个月后，测定血清17β - 雌二醇、促卵泡激素（FSH）、褪黑素水平以及尿6 - 硫酸氧基褪黑素（aMT6s）排泄量，同时测定库珀曼指数（KI）和体重指数（BMI）。在第一组中，仅KI值略有下降（28.4 ± 2.9对25.6 ± 3.8分，P = 0.0619）。在第二组中，KI从29.1 ± 2.9降至19.7 ± 3.1分（P < 0.001），BMI从30.9 ± 2.9降至28.1 ± 2.3 kg/m²（P < 0.05）。补充褪黑素未能显著改变女性生殖激素17β - 雌二醇和FSH的血清浓度。我们得出结论，补充褪黑素疗法对绝经后女性的身心症状有积极作用，可作为治疗这些失调症状的有效辅助治疗选择。
