Wolfarth S, Kolasiewicz W, Ossowska K
Behav Brain Res. 1985 Dec;18(3):261-8. doi: 10.1016/0166-4328(85)90034-8.
The aim of the study was to determine to what extent catalepsy and tonic rigidity of muscles induced by muscimol administration into the ventral thalamic nuclei disturb the motor activity of rats. This study also aimed to test whether the ventromedial thalamic nucleus (Vm) was involved in transmitting effects evoked by the systemic injection of neuroleptics or opioids. For this purpose muscimol and/or picrotoxin was injected into the ventral thalamic nuclei and the behaviour of the animals was assessed in a series of test situations. It was found that muscimol administration to the Vm disturbs not only the initiation and performance of voluntary movements but also the occurrence of avoidance when the animal's life is endangered. Postural reflexes remained, however, undisturbed. Those effects seemed to be GABA- and site-specific to Vm. The haloperidol catalepsy was strongly inhibited by administration of picrotoxin to the Vm while the morphine catalepsy remained unchanged after picrotoxin. The Vm plays a crucial role in the motor behaviour and transmission of cataleptogenic effects of haloperidol, whereas similar effects produced by morphine appear to by-pass the investigated thalamic region.
本研究的目的是确定向腹侧丘脑核注射蝇蕈醇所诱导的肌肉僵住症和强直性僵硬在多大程度上干扰大鼠的运动活动。本研究还旨在测试腹内侧丘脑核（Vm）是否参与传递全身注射抗精神病药物或阿片类药物所诱发的效应。为此，将蝇蕈醇和/或印防己毒素注入腹侧丘脑核，并在一系列测试情境中评估动物的行为。研究发现，向Vm注射蝇蕈醇不仅会干扰自主运动的启动和执行，还会在动物生命受到威胁时干扰回避行为的发生。然而，姿势反射并未受到干扰。这些效应似乎对Vm具有GABA和位点特异性。向Vm注射印防己毒素可强烈抑制氟哌啶醇僵住症，而注射印防己毒素后吗啡僵住症保持不变。Vm在氟哌啶醇的运动行为和僵住症效应传递中起关键作用，而吗啡产生的类似效应似乎绕过了所研究的丘脑区域。
