Kolasiewicz W, Wolfarth S, Ossowska K
Department of Neuropharmacology, Polish Academy of Sciences, Kraków.
Neurosci Lett. 1988 Jul 19;90(1-2):219-23. doi: 10.1016/0304-3940(88)90815-4.
Picrotoxin (25, 50 and 100 ng), injected unilaterally into the posterior part of the substantia nigra pars reticulata (SNR) of rats, evoked a dose-dependent catalepsy. The catalepsy evoked by 100 ng of picrotoxin injected into the SNR was abolished by a subsequent bilateral injection of the same drug (200 ng) into the ventromedial thalamic nuclei. It is suggested that impulses pertinent to the catalepsy evoked from the SNR are transmitted via a GABAergic pathway to the ventromedial thalamic nucleus, wherefrom they reach the striatum, as had been shown previously.
印防己毒素（25、50和100纳克）单侧注射到大鼠黑质网状部（SNR）后部，可诱发剂量依赖性僵住症。向SNR注射100纳克印防己毒素所诱发的僵住症，可通过随后向丘脑腹内侧核双侧注射相同药物（200纳克）而消除。这表明，与从SNR诱发的僵住症相关的冲动是通过一条γ-氨基丁酸能通路传递至丘脑腹内侧核，如先前所示，这些冲动从该核到达纹状体。
