Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Dis Markers. 2018 Jun 25;2018:6345284. doi: 10.1155/2018/6345284. eCollection 2018.
Recent studies have demonstrated that miRNA-155 is involved in the occurrence and development of atherosclerosis. Furthermore, miRNA-155 has emerged as a new indirect marker for inflammation associated with adverse outcomes in oncology and cardiovascular diseases. This study investigated the correlation between the levels of miRNA-155 and coronary slow flow (CSF).
A total of 66 patients with CSF and 66 patients with normal coronary flow were enrolled in this study. Coronary flow velocity was determined using the thrombolysis in myocardial infarction frame count (TFC) method. The plasma levels of miRNA-155 were quantified using real-time quantitative polymerase chain reaction.
The plasma levels of miRNA-155 were significantly higher in the CSF group compared to the control group ( < 0.05). In addition, miRNA-155 levels were positively correlated with TFC and high-sensitivity C-reactive protein (hs-CRP) levels ( < 0.05 for both parameters). Multivariate linear regression analysis demonstrated that plasma miRNA-155 (OR = 2.384, 95% confidence interval 1.847-3.273, = 0.032) and hs-CRP (OR = 1.273, 95% confidence interval 1.036-2.253, = 0.013) were independent predictors for CSF. Using plasma miRNA-155 levels as the test variable, ROC curve analysis indicated that the area under the curve was 0.782 ( < 0.05).
Patients with CSF have higher plasma levels of miRNA-155, and this may play an important role in the pathogenesis of CSF, and an elevated plasma miRNA-155 level may be a predictor for CSF. A large-scale and multicenter study is required to elucidate the role of miRNA-155 as a potential biomarker for patients with CSF.
最近的研究表明，miRNA-155 参与了动脉粥样硬化的发生和发展。此外，miRNA-155 已成为肿瘤学和心血管疾病中与不良结局相关的炎症的新的间接标志物。本研究探讨了 miRNA-155 水平与冠状动脉慢血流（CSF）之间的相关性。
共纳入 66 例 CSF 患者和 66 例正常冠状动脉血流患者。使用心肌梗死溶栓帧数（TFC）法测定冠状动脉血流速度。采用实时定量聚合酶链反应（PCR）定量测定 miRNA-155 的血浆水平。
CSF 组患者的血浆 miRNA-155 水平明显高于对照组（ < 0.05）。此外，miRNA-155 水平与 TFC 和高敏 C 反应蛋白（hs-CRP）水平呈正相关（两个参数均 < 0.05）。多元线性回归分析表明，血浆 miRNA-155（OR=2.384，95%置信区间 1.847-3.273， = 0.032）和 hs-CRP（OR=1.273，95%置信区间 1.036-2.253， = 0.013）是 CSF 的独立预测因子。使用血浆 miRNA-155 水平作为检验变量，ROC 曲线分析表明曲线下面积为 0.782（ < 0.05）。
CSF 患者的血浆 miRNA-155 水平较高，这可能在 CSF 的发病机制中发挥重要作用，而血浆 miRNA-155 水平升高可能是 CSF 的预测因子。需要进行大规模、多中心研究，以阐明 miRNA-155 作为 CSF 患者潜在生物标志物的作用。
