Goffinet A M, Hemmendinger L M, Caviness V S
Brain Res. 1986 Jan;389(1-2):187-91. doi: 10.1016/0165-3806(86)90186-0.
The development of beta 1-adrenergic receptors has been studied in the mouse forebrain from embryonic day 14 (E14) to adulthood, using autoradiographic visualization of [125I]iodocyanopindolol (ICYP) binding sites. From E14, ICYP binding sites are detected in moderate amounts in the striatum and basal forebrain and in very low concentration in the cortical plate. At E17, binding sites have increased in number in the deep layers of the embryonic cortex and extend over the whole thickness of the cortical ribbon at birth. On postnatal day 4 (P4), ICYP binding sites are more abundant in the superficial than in the inner cortex. By P10 the adult pattern of ICYP binding site distribution is achieved, namely: a high concentration in ventral pallidum, striatum and cortical layers I, II and III, a moderate concentration in layers V and VI and a lower density in septal areas and in cortical layer IV. It is well established that norepinephrine fibers arrive in the embryonic cortex early in development. The present results show that the development of norepinephrine fiber and beta 1 receptor systems are coincident in the mouse.
利用放射自显影技术可视化[125I]碘氰吲哚洛尔（ICYP）结合位点，对小鼠前脑从胚胎第14天（E14）到成年期β1 - 肾上腺素能受体的发育进行了研究。从E14开始，在纹状体和基底前脑检测到适量的ICYP结合位点，而在皮质板中浓度极低。在E17时，胚胎皮质深层的结合位点数量增加，出生时延伸至整个皮质带厚度。在出生后第4天（P4），ICYP结合位点在皮质浅层比深层更丰富。到P10时，实现了ICYP结合位点分布的成年模式，即：腹侧苍白球、纹状体以及皮质I、II和III层中浓度高，V层和VI层浓度适中，隔区和皮质IV层密度较低。众所周知，去甲肾上腺素纤维在发育早期到达胚胎皮质。目前的结果表明，去甲肾上腺素纤维和β1受体系统在小鼠中的发育是同步的。
