两种与类风湿关节炎患者疾病活动评分-28 相关的新炎症标志物：白蛋白与纤维蛋白原比值和 C 反应蛋白与白蛋白比值。
Two new inflammatory markers associated with disease activity score-28 in patients with rheumatoid arthritis: Albumin to fibrinogen ratio and C-reactive protein to albumin ratio.
机构信息
Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Department of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
出版信息
Int Immunopharmacol. 2018 Sep;62:293-298. doi: 10.1016/j.intimp.2018.07.007. Epub 2018 Jul 23.
BACKGROUND
The albumin to fibrinogen ratio (AFR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between AFR/CAR and Disease Activity Score of 28 joints (DAS 28) in rheumatoid arthritis (RA).
METHODS
This retrospective study included 160 patients with RA and 159 healthy controls. We divided the RA patients into two groups according to the DAS 28-ESR score. Group 1 included 40 patients with a score of lower than 2.6 (patients in remission) and Group 2 included 120 patients with a score of 2.6 or higher (patients with active disease). The correlations between AFR, CAR and the disease activity were analyzed.
RESULTS
For RA patients, the AFR was lower than those in the control group (P < 0.001). Patients in group 2 had higher CAR than those in group 1 (P < 0.001). The AFR was lower in group 2 than that in group 1. A positively correlation was observed between DAS 28-ESR score and CAR (r = 0.645, P < 0.001), while the correlation between DAS 28-ESR and AFR (r = -0.836, P < 0.001) was negative. AFR was related with decreased risk of RA disease activity (EXP (B) = 0.33, 95% CI (0.21-0.53), P < 0.001).
CONCLUSIONS
AFR and CAR are two novel inflammatory markers for monitoring disease activity in patients with RA.
背景
白蛋白与纤维蛋白原比值（AFR）和 C 反应蛋白与白蛋白比值（CAR）已成为预测全身炎症的有用生物标志物。本研究旨在探讨类风湿关节炎（RA）患者中 AFR/CAR 与 28 关节疾病活动度评分（DAS 28）的关系。
方法
本回顾性研究纳入了 160 例 RA 患者和 159 名健康对照者。我们根据 DAS 28-ESR 评分将 RA 患者分为两组。第 1 组包括 40 名评分低于 2.6（缓解期患者），第 2 组包括 120 名评分 2.6 或更高（活动期患者）的患者。分析了 AFR、CAR 与疾病活动的相关性。
结果
RA 患者的 AFR 低于对照组（P<0.001）。第 2 组患者的 CAR 高于第 1 组（P<0.001），且第 2 组的 AFR 低于第 1 组。DAS 28-ESR 评分与 CAR 之间呈正相关（r=0.645，P<0.001），而 DAS 28-ESR 与 AFR 之间呈负相关（r=-0.836，P<0.001）。AFR 与 RA 疾病活动减少的风险相关（EXP（B）=0.33，95%CI（0.21-0.53），P<0.001）。
结论
AFR 和 CAR 是监测 RA 患者疾病活动的两种新的炎症标志物。
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