Division of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.
Atherosclerosis. 2018 Sep;276:83-90. doi: 10.1016/j.atherosclerosis.2018.07.006. Epub 2018 Jul 17.
Type 2 diabetes is a global health problem that is associated with a wide variety of vascular complications and associated morbidity and mortality. Klotho is an enzyme and transmembrane protein, and increasing evidence suggests that Klotho may contribute to reduced oxidative stress, improved endothelial function, and vasoprotection. To date, the physiological role of Klotho in vascular complications associated with diabetes is unclear.
We prospectively recruited 252 patients with type 2 diabetes, who visited an outpatient clinic at our hospital between 2009 and 2011. Patients in the top and bottom tertiles of circulating Klotho levels were enrolled for analysis.
Of the 168 patients enrolled, 45.8% were male, the mean age was 57.2 years, and the average duration of diabetes was 7.58 years. In multiple regression analysis, a high Klotho level was associated with a reduced risk of developing coronary artery disease and cerebrovascular accidents. Klotho level was also an independent predictor for the development of macroangiopathies within the 7-year study period.
Our results suggest that circulating Klotho level is a predictor of long-term macrovascular outcomes in patients with type 2 diabetes.
2 型糖尿病是一种全球性的健康问题，与多种血管并发症以及相关发病率和死亡率相关。Klotho 是一种酶和跨膜蛋白，越来越多的证据表明 Klotho 可能有助于减少氧化应激、改善内皮功能和血管保护。迄今为止，Klotho 在与糖尿病相关的血管并发症中的生理作用尚不清楚。
我们前瞻性地招募了 2009 年至 2011 年间在我院门诊就诊的 252 例 2 型糖尿病患者。招募了循环 Klotho 水平处于最高和最低三分位数的患者进行分析。
在纳入的 168 例患者中，45.8%为男性，平均年龄为 57.2 岁，糖尿病平均病程为 7.58 年。在多因素回归分析中，高 Klotho 水平与发生冠状动脉疾病和脑血管意外的风险降低相关。Klotho 水平也是 7 年内发生大血管病变的独立预测因子。
我们的研究结果表明，循环 Klotho 水平是 2 型糖尿病患者长期大血管结局的预测因子。
