University Cardiology Clinic and the Vascular Centre, Skopje, Macedonia.
Faculty of Medicine, Skopje, Macedonia.
Clin Appl Thromb Hemost. 2018 Dec;24(9_suppl):84S-88S. doi: 10.1177/1076029618786577. Epub 2018 Jul 26.
The article's aim was to determine predictors for short- and long-term prognosis of patients with pulmonary embolism (PE). Cohort prospective study based on the National registry on venous thromboembolism. Eighty-four patients with PE, on age 60.3 + 12.5 years, were selected and followed up in a prospective study. Pulmonary embolism was confirmed by computed tomography angiography in all the patients, while deep venous thrombosis was confirmed by ultrasound in 21 patients. Study population was followed up for 6.7 months. Multivariate regression analysis was done where right ventricular (RV) diameter (mean 37.5 mm), systolic pulmonary artery pressure (68 ± 23 mm Hg) measured by echocardiography, d-dimer level at baseline 2654.5 ± 420.3 ng/mL, number of comorbidities (2.4 ± 0.7), and present symptoms (3.1 ± 0.9) entered the model. The model was age-adjusted. d-dimer level was revealed as a predictor for the length of hospitalization (β = .25, .05) and RV diameter as a factor for duration of anticoagulation (β = .29, .05). Our results imply that the baseline measurement of these parameters independently influence both the short-term and long-term prognosis of patients with nonfatal PE.
本文旨在确定肺栓塞（PE）患者短期和长期预后的预测因素。这是一项基于全国静脉血栓栓塞登记处的前瞻性队列研究。选择了 84 名年龄为 60.3 + 12.5 岁的 PE 患者，并在一项前瞻性研究中进行随访。所有患者均通过计算机断层扫描血管造影术确诊为肺栓塞，而 21 例患者通过超声检查确诊为深静脉血栓形成。研究人群的随访时间为 6.7 个月。进行了多变量回归分析，其中右心室（RV）直径（平均 37.5mm）、超声测量的收缩期肺动脉压（68 ± 23mmHg）、基线 d-二聚体水平 2654.5 ± 420.3ng/mL、合并症数量（2.4 ± 0.7）和当前症状（3.1 ± 0.9）进入模型。该模型经过年龄调整。d-二聚体水平是住院时间（β=.25，.05）的预测因素，RV 直径是抗凝时间（β=.29，.05）的影响因素。我们的研究结果表明，这些参数的基线测量值独立影响非致命性 PE 患者的短期和长期预后。
