Atashi Vajihe, Yazdannik Ahmadreza, Mahjobipoor Hosein, Ghafari Somayeh, Bekhradi Reza, Yousefi Hojatollah
Students' Research Committee, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Critical Care Nursing, Nursing and Midwifery School, Nursing and Midwifery Care Research Center, Isfahan University of Medical Science, Isfahan, Iran.
J Res Pharm Pract. 2018 Apr-Jun;7(2):104-110. doi: 10.4103/jrpp.JRPP_18_21.
Mouth dryness is one of the most prevalent problems in Intensive Care Units (ICUs). It facilitates dental plaque formation. The aim of this study was to analyze the effects of -Peppermint (Veramin) moisturizing gel on mouth dryness and oral health among patients hospitalized in ICUs.
This triple-blind two-group randomized placebo-controlled clinical trial was undertaken in 2016-2017 on a convenient sample of 80 patients. Patients were randomly allocated to an intervention and a placebo group. Oral care for patients in the intervention and the placebo groups was provided for 5 successive days using Veramin moisturizing gel and a placebo gel, respectively. Data were collected at the 1, 3, and 5 days of the study using a demographic and clinical characteristics questionnaire, the Challacombe scale (for mouth dryness assessment), and the Mucosal-Plaque Index (for oral health assessment). The Chi-square, Fisher Exact, Mann-Whitney U, and Friedman tests were used for data analysis.
In the 5 day, the mean score of mouth dryness in the intervention group was significantly lower than the placebo group ( = 0.0001). On the other hand, in the third and the 5 days, the oral health mean score in the intervention group was significantly lower than the placebo group ( = 0.0001).
Veramin moisturizing gel is effective in significantly relieving mouth dryness, preventing dental plaque formation, and improving oral health. Thus, it can be used for improving oral care outcomes in ICUs.
口干是重症监护病房（ICU）中最普遍的问题之一。它会促进牙菌斑的形成。本研究的目的是分析薄荷（Veramin）保湿凝胶对ICU住院患者口干及口腔健康的影响。
2016 - 2017年对80例方便抽样患者进行了这项三盲两组随机安慰剂对照临床试验。患者被随机分为干预组和安慰剂组。分别使用Veramin保湿凝胶和安慰剂凝胶为干预组和安慰剂组患者连续进行5天的口腔护理。在研究的第1、3和5天，使用人口统计学和临床特征问卷、查拉科姆量表（用于口干评估）和黏膜菌斑指数（用于口腔健康评估）收集数据。采用卡方检验、Fisher精确检验、曼 - 惠特尼U检验和弗里德曼检验进行数据分析。
在第5天，干预组的口干平均得分显著低于安慰剂组（P = 0.0001）。另一方面，在第3天和第5天，干预组的口腔健康平均得分显著低于安慰剂组（P = 0.0001）。
Veramin保湿凝胶在显著缓解口干、预防牙菌斑形成和改善口腔健康方面有效。因此，它可用于改善ICU中的口腔护理效果。
