Nair Gopakumar Ramachandran, Naidu Giridhar Seetharam, Jain Supreet, Nagi Ravleen, Makkad Ramanpal Singh, Jha Abhishek
Ex-Professor and Head, Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute , Sakri, Bilaspur, India .
Professor, Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute , Sakri, Bilaspur, India .
J Clin Diagn Res. 2016 Aug;10(8):ZE01-7. doi: 10.7860/JCDR/2016/18142.8222. Epub 2016 Aug 1.
Aloe vera is well known for its medicinal properties which lead to its application in treating various diseases. Its use in treating oral lesions has not been much documented in literature.
Although, systematic reviews on aloe vera and its extracts have been done earlier, but in relation to oral diseases this is the first systematic review. The aim of the present systematic review was to compile evidence based studies on the effectiveness of Aloe vera in treatment of various oral diseases.
Computerized literature searches were performed to identify all published articles in the subject. The following databases were used: PUBMED [MEDLINE], SCOPUS, COCHRANE DATABASE, EMBASE and SCIENCE DIRECT using specific keywords. The search was limited to articles published in English or with an English Abstract. All articles (or abstracts if available as abstracts) were read in full. Data were extracted in a predefined fashion. Assessment was done using Jadad score.
Fifteen studies satisfied the inclusion criteria. Population of sample study ranged from 20 patients to 110 patients with clinically diagnosed oral mucosal lesions. Out of 15 studies, five were on patients with oral lichen planus, two on patients with oral submucous fibrosis, other studies were carried on patients with burning mouth syndrome, radiation induced mucositis, candida associated denture stomatitis, xerostomic patients and four were on minor recurrent apthous stomatitis. Most studies showed statistically significant result demonstrating the effectiveness of Aloe vera in treatment of oral diseases.
Although there are promising results but in future, more controlled clinical trials are required to prove the effectiveness of Aloe vera for management of oral diseases.
芦荟因其药用特性而闻名，这使其被应用于治疗各种疾病。然而，其在治疗口腔病变方面的应用在文献中记载较少。
虽然此前已经对芦荟及其提取物进行了系统评价，但针对口腔疾病的这是首次系统评价。本系统评价的目的是汇编基于证据的关于芦荟治疗各种口腔疾病有效性的研究。
进行计算机文献检索以识别该主题下所有已发表的文章。使用了以下数据库：PUBMED [MEDLINE]、SCOPUS、Cochrane数据库、EMBASE和科学Direct，使用特定关键词。检索限于以英文发表或带有英文摘要的文章。所有文章（若仅有摘要则阅读摘要）均全文阅读。数据以预定义方式提取。使用Jadad评分进行评估。
15项研究符合纳入标准。样本研究的人群包括20例至110例临床诊断为口腔黏膜病变的患者。在这15项研究中，5项针对口腔扁平苔藓患者，2项针对口腔黏膜下纤维化患者，其他研究针对灼口综合征、放射性口腔黏膜炎、念珠菌相关性义齿性口炎、口干症患者，还有4项针对轻型复发性阿弗他口炎患者。大多数研究显示出统计学上显著的结果，证明芦荟在治疗口腔疾病方面的有效性。
尽管有令人鼓舞的结果，但未来需要更多对照临床试验来证明芦荟在口腔疾病管理中的有效性。
