Barnard J A, Marshall G S, Neblett W W, Gray G, Ghishan F K
Gastroenterology. 1986 Apr;90(4):1054-6. doi: 10.1016/0016-5085(86)90888-7.
A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy.
一名9岁女孩在接受肾母细胞瘤综合治疗2年后出现食管静脉曲张大量出血。评估显示肝外门静脉系统通畅，脾髓压升高。与先前关于放射损伤后肝病的报道不同，肝脏组织切片未显示中央静脉闭塞，而是肝内门静脉分支弥漫性闭塞。这种非肝硬化性门静脉纤维化的模式在抗肿瘤治疗后尚未见报道。
