Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.
Sleep. 2018 Oct 1;41(10). doi: 10.1093/sleep/zsy143.
To examine the association between changes in sleep duration and the risk of incident dementia in the elderly.
In 2006, we conducted a cohort study of 7422 disability-free Japanese individuals aged ≥65 years who lived in Ohsaki City, Japan. In both 1994 and 2006, the individual amount of sleep obtained was assessed using a self-reported questionnaire. Based on sleep duration at these two time points, participants were categorized into five groups according to the change in sleep duration. Data on incident dementia were retrieved from the public Long-term Care Insurance database, and the subjects were followed up for 5.7 years (between April 2007 and November 2012). The Cox proportional hazards model was used to estimate the multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for incident dementia.
During 36338 person-years of follow up, 688 cases of incident dementia were documented. Compared with subjects who had no change in sleep duration, the multivariate HRs (95% CIs) of incident dementia were 1.31 (1.07 to 1.60) for those whose sleep duration increased by 1 hr, and 2.01 (1.51 to 2.69) for an increase of ≥2 hr.
Increased sleep duration is associated with a significantly higher risk of incident dementia in the elderly. Future studies using well-validated measurements are needed to confirm the association between sleep and dementia.
探讨老年人睡眠时间变化与痴呆症发病风险的关系。
我们于 2006 年对日本大阪市的 7422 名无残疾的 65 岁及以上老年人进行了一项队列研究。在 1994 年和 2006 年，使用自我报告问卷评估个体的睡眠时间。根据这两个时间点的睡眠时间，参与者根据睡眠时间的变化分为五组。从公共长期护理保险数据库中检索到痴呆症发病的数据，对受试者进行了 5.7 年的随访（2007 年 4 月至 2012 年 11 月）。使用 Cox 比例风险模型估计痴呆症发病的多变量调整后的风险比（HRs）和 95%置信区间（95%CI）。
在 36338 人年的随访期间，记录到 688 例痴呆症发病。与睡眠时间无变化的受试者相比，睡眠时间增加 1 小时的发病 HR（95%CI）为 1.31（1.07 至 1.60），增加≥2 小时的发病 HR 为 2.01（1.51 至 2.69）。
老年人睡眠时间增加与痴呆症发病风险显著增加相关。需要使用经过良好验证的测量方法进行未来的研究，以确认睡眠与痴呆症之间的关系。
