胃癌患者中胃蛋白酶原和幽门螺杆菌感染与 Epstein-Barr 病毒感染的关系。

Epstein-Barr virus infection associated with pepsinogens and Helicobacter pylori infection in patients with gastric cancer.

机构信息

Department of Head and Neck, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, China.

Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

出版信息

Virus Res. 2018 Sep 2;256:1-5. doi: 10.1016/j.virusres.2018.07.017. Epub 2018 Jul 24.

DOI:10.1016/j.virusres.2018.07.017

PMID:30053417

Abstract

BACKGROUND

There is no study reporting the influence of the Epstein-Barr virus (EBV) infection on the biomarkers of gastric function like pepsinogen (PG) I and II in patients with gastric cancer, and the relationship between the infection of EBV and Helicobacter pylori (HP) is unclear. This study focused on these issues.

METHODS

In this study, we detected the serum levels of PGI, PGII, anti-HP (immunoglobulin G) IgG antibodies and EBV DNA load in a total of 189 gastric cancer patients confirmed to be EBV positive or negative in tissue using in situ hybridization of EBV-encoded small RNAs (EBERs).

RESULTS

Compared to 123 EBV negative gastric cancer patients, the 66 patients infected with EBV exhibited significant higher levels of PGI and PGI/II ratio and meanwhile, had remarkably lower levels of anti-HP IgG. The prevalence of HP infection in EBV positive patients was 13.6%, and 52.8% in EBV negative patients. In subsequent analysis concerning the EBV DNA load, the patients were divided into two groups by a cutoff value of 1000 copies/ml. The EBV DNA load showed highly consistent association with PGI, PGI/II ratio and HP.

CONCLUSIONS

EBV infection in situ increased the serum levels of PGI and ratio of PGI/PGII in gastric cancer patients. Moreover, the EBV infection exclusively exists with HP infection in the patients with gastric cancer.

摘要

背景

目前尚无研究报道 EBV 感染对胃癌患者胃功能生物标志物如胃蛋白酶原（PG）I 和 II 的影响，以及 EBV 与幽门螺杆菌（HP）感染之间的关系。本研究主要针对这些问题。

方法

本研究采用 EBV 编码小 RNA（EBERs）原位杂交法，检测了 189 例组织学证实 EBV 阳性或阴性的胃癌患者血清 PG I、PG II、抗-HP（IgG 抗体）和 EBV DNA 载量。

结果

与 123 例 EBV 阴性胃癌患者相比，66 例 EBV 感染患者的 PG I 和 PG I/II 比值明显升高，而抗-HP IgG 水平明显降低。EBV 阳性患者的 HP 感染率为 13.6%，EBV 阴性患者为 52.8%。在进一步分析 EBV DNA 载量时，根据 1000 拷贝/ml 的临界值将患者分为两组。EBV DNA 载量与 PG I、PG I/PG II 比值和 HP 高度一致。