Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong university of Science and Technology, Wuhan 430030 Hubei Province, China.
Int J Med Sci. 2022 May 21;19(5):924-931. doi: 10.7150/ijms.71820. eCollection 2022.
About 10% of gastric cancer (GC) has been described to be Epstein-Barr virus (EBV) positive. Previous researches have described the association between EBV and GC. However, the association of EBV with atrophic gastritis (AG) is underrecognized. Our study aimed to investigate the relationship between EBV and AG and assess the influence of EBV on gastric function. A total of 468 pathologically-confirmed chronic gastritis patients underwent circulating EBV DNA test, include 271 non-atrophic gastritis (NAG) and 197 AG patients. In this study, infection rate was 33.3%, EBV infection rate was 40%, and co-infection rate was 15%. The EBV DNA-positive was significantly associated with AG (=0.031, OR= 1.509, 95% CI 1.037-2.194), especially in -negative subjects (=0.044, OR=1.619, 95% CI 1.012-2.589). EBV DNA-positive patients had a lower pepsinogen I (PG I) / pepsinogen II (PG II) ratio (PGR) than EBV DNA-negative patients (=0.0026), especially in the AG subgroup (=0.0062). There was no significant association between EBV and co-infection with increased risk of AG (>0.05). EBV infection significantly increased the risk of AG, especially in -negative patients. The circulating EBV DNA had a potential in predicting the risk of atrophic gastritis.
约 10%的胃癌（GC）已被描述为 Epstein-Barr 病毒（EBV）阳性。先前的研究已经描述了 EBV 与 GC 之间的关联。然而，EBV 与萎缩性胃炎（AG）之间的关联尚未被充分认识。我们的研究旨在探讨 EBV 与 AG 之间的关系，并评估 EBV 对胃功能的影响。
总共 468 例经病理证实的慢性胃炎患者接受了循环 EBV DNA 检测，包括 271 例非萎缩性胃炎（NAG）和 197 例 AG 患者。在这项研究中，感染率为 33.3%，EBV 感染率为 40%，合并感染率为 15%。EBV DNA 阳性与 AG 显著相关（=0.031，OR=1.509，95%CI 1.037-2.194），尤其是在 - 阴性受试者中（=0.044，OR=1.619，95%CI 1.012-2.589）。EBV DNA 阳性患者的胃蛋白酶原 I（PG I）/胃蛋白酶原 II（PG II）比值（PGR）低于 EBV DNA 阴性患者（=0.0026），尤其是在 AG 亚组中（=0.0062）。EBV 与 合并感染之间没有显著关联，增加 AG 的风险（>0.05）。
EBV 感染显著增加了 AG 的风险，尤其是在 - 阴性患者中。循环 EBV DNA 具有预测萎缩性胃炎风险的潜力。
