Delaere Pierre, Lerut Toni, Van Raemdonck Dirk
Department of Otorhinolaryngology Head and Neck Surgery, University of Leuven, Herestraat 49, Leuven B-3000, Belgium.
Department of Thoracic Surgery, University Hospitals Leuven, UZ Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium.
Thorac Surg Clin. 2018 Aug;28(3):337-345. doi: 10.1016/j.thorsurg.2018.05.002.
The trachea is one of the most difficult organs to transplant because its segmental blood supply involves blood vessels that are too small to allow for microvascular anastomosis. Through an ingenious sequence of revascularization and wound-healing mechanisms under temporary immunosuppression, the authors have developed a tracheal allotransplantation technique that allows the creation of a true chimeric trachea. The donor component of this chimeric trachea is tolerated permanently based on immune ignorance. This technique holds great promise for the development of a standardized approach for the repair of large tracheal defects.
气管是最难进行移植的器官之一，因为其节段性血供所涉及的血管过于细小，无法进行微血管吻合。通过在临时免疫抑制下巧妙的一系列血管再生和伤口愈合机制，作者们开发出了一种气管同种异体移植技术，该技术能够构建出真正的嵌合气管。基于免疫忽视，这种嵌合气管的供体成分能够被永久耐受。这项技术为开发修复大段气管缺损的标准化方法带来了巨大希望。
