Division of Depression and Anxiety Disorders, McLean Hospital Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.
Nat Rev Neurosci. 2018 Sep;19(9):535-551. doi: 10.1038/s41583-018-0039-7.
Post-traumatic stress disorder (PTSD) is a prevalent, debilitating and sometimes deadly consequence of exposure to severe psychological trauma. Although effective treatments exist for some individuals, they are limited. New approaches to intervention, treatment and prevention are therefore much needed. In the past few years, the field has rapidly developed a greater understanding of the dysfunctional brain circuits underlying PTSD, a shift in understanding that has been made possible by technological revolutions that have allowed the observation and perturbation of the macrocircuits and microcircuits thought to underlie PTSD-related symptoms. These advances have allowed us to gain a more translational knowledge of PTSD, have provided further insights into the mechanisms of risk and resilience and offer promising avenues for therapeutic discovery.
创伤后应激障碍（PTSD）是暴露于严重心理创伤后的一种普遍、衰弱且有时致命的后果。尽管一些个体存在有效的治疗方法，但这些方法是有限的。因此，非常需要新的干预、治疗和预防方法。在过去的几年中，该领域迅速加深了对 PTSD 相关大脑功能障碍回路的理解，这种理解的转变得益于技术革命，这些革命使我们能够观察和干扰被认为与 PTSD 相关症状有关的宏回路和微回路。这些进展使我们能够获得更多有关 PTSD 的转化知识，进一步深入了解风险和弹性的机制，并为治疗发现提供了有前途的途径。
