Akarsu M, Atalay H A, Canat L, Ozcan M, Arman Y, Aydın S, Cil E, Kutlu O, Tükek T
Department of Internal Medicine, Okmeydanı Training and Research Hospital, Sisli-Istanbul, Turkey.
Department of Urology, Okmeydanı Training and Research Hospital, Sisli-Istanbul, Turkey.
Andrologia. 2018 Apr;50(3). doi: 10.1111/and.12912. Epub 2017 Oct 23.
This study aimed to measure the serum endocan level of patients with erectile dysfunction (ED) and to investigate the possible association between this and vasculogenic severe ED. We performed a prospective analysis of 86 consecutive patients affected by ED. Patients were divided into severe ED (IIEF-5 score < 7) and mild or moderate ED (IIEF-5 score > 7). A strong negative correlation was found between serum endocan levels and peak systolic velocity (p < .001 and r = -.665) in men with severe ED. Univariate logistic regression analysis demonstrated that tobacco consumption (p < .05), serum total 25-hydroxyvitamin D (p < .01), serum endocan levels (p < .01), peak systolic velocity (p < .01), hypertension (p < .001), dyslipidaemia (p < .001), metabolic syndrome (p = .026) and a history of a cardiovascular event (p < .001) significantly increase the risk of severe ED. In the multivariate logistic regression model, we also found that age, hypertension, metabolic syndrome, cardiovascular events and higher serum endocan levels were independently associated with severe ED. Circulating endocan may be used in daily practice as a new marker that correlates with cardiovascular risks and the severity of ED disease.
本研究旨在测量勃起功能障碍（ED）患者的血清内脂素水平，并探究其与血管源性重度ED之间的可能关联。我们对86例连续性ED患者进行了前瞻性分析。患者被分为重度ED组（国际勃起功能指数-5评分<7）和轻度或中度ED组（国际勃起功能指数-5评分>7）。在重度ED男性中，血清内脂素水平与收缩期峰值流速之间存在强烈的负相关性（p<.001，r = -.665）。单因素逻辑回归分析表明，吸烟（p<.05）、血清总25-羟维生素D（p<.01）、血清内脂素水平（p<.01）、收缩期峰值流速（p<.01）、高血压（p<.001）、血脂异常（p<.001）、代谢综合征（p =.026）和心血管事件史（p<.001）显著增加了重度ED的风险。在多因素逻辑回归模型中，我们还发现年龄、高血压、代谢综合征、心血管事件和较高的血清内脂素水平与重度ED独立相关。循环内脂素在日常实践中可作为一种与心血管风险和ED疾病严重程度相关的新标志物。
