Demirel Doruk, Aktas Binhan Kagan, Kosem Arzu, Soydas Turker, Akpinar Cagri, Ozgur Emrah Gökay, Ozden Cuneyt, Kayigil Onder
Department of Urology, Ankara Etlik City Hospital, Ankara, Turkey.
Department of Urology, Ankara Bilkent City Hospital, Ankara, Turkey.
Medicine (Baltimore). 2025 Mar 14;104(11):e41742. doi: 10.1097/MD.0000000000041742.
To evaluate the relationship between serum endothelial cell specific molecule-1 (Endocan), asymmetric dimethylarginine (ADMA) values, and penile Doppler ultrasonography (USG) findings in patients with severe erectile dysfunction (ED). This prospective study included 73 patients who were classified as severe ED and had an indication for penile Doppler USG in our urology outpatient clinic between April 2017 and January 2020. Fasting blood sugar, lipid profile, thyroid function tests, total testosterone, and serum Endocan and ADMA values were sampled, and penile Doppler USG examination data were recorded. Vasculogenic ED was detected in 51 (69.86%) of 73 patients, while the flow rates were normal in 22 (30.14%). Among those with vasculogenic ED, 15 (29.41%) had arterial insufficiency, 22 (43.13%) had venous leakage, and 14 (27.46%) had mixed. There was no statistically significant difference between the mean ADMA and Endocan values of ED with normal flow (14.44 ± 6.20 ng/mL and 0.18 ± 0.14 ng/mL) and the vasculogenic ED (12.31 ± 5.86 ng/mL and 0.21 ± 0.16 ng/mL) groups (P = .097 for ADMA and P = .315 for Endocan, respectively). Endocan and ADMA levels were not predictors of severe ED. There is a need for multicenter studies with larger patient populations to be conducted with different biomarkers that may have a higher predictive value in the future.
评估重度勃起功能障碍（ED）患者血清内皮细胞特异性分子-1（Endocan）、不对称二甲基精氨酸（ADMA）值与阴茎多普勒超声检查（USG）结果之间的关系。这项前瞻性研究纳入了73例被归类为重度ED且在2017年4月至2020年1月期间在我们泌尿外科门诊有阴茎多普勒USG检查指征的患者。采集空腹血糖、血脂谱、甲状腺功能检查、总睾酮以及血清Endocan和ADMA值，并记录阴茎多普勒USG检查数据。73例患者中有51例（69.86%）检测出血管性ED，而22例（30.14%）的血流速度正常。在血管性ED患者中，15例（29.41%）存在动脉供血不足，22例（43.13%）存在静脉漏，14例（27.46%）为混合型。血流正常的ED患者（14.44 ± 6.20 ng/mL和0.18 ± 0.14 ng/mL）与血管性ED患者（12.31 ± 5.86 ng/mL和0.21 ± 0.16 ng/mL）的平均ADMA和Endocan值之间无统计学显著差异（ADMA分别为P = 0.097，Endocan为P = 0.315）。Endocan和ADMA水平不是重度ED的预测指标。未来需要开展针对更大患者群体的多中心研究，使用可能具有更高预测价值的不同生物标志物。
