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猫对吡罗昔康可能的皮肤药物不良反应。

Probable cutaneous adverse drug reaction to piroxicam in a cat.

作者信息

Young Amanda J, Torres Sheila M, Koch Sandra N

机构信息

Veterinary Clinical Sciences, University of Minnesota, St Paul, MN, USA.

出版信息

JFMS Open Rep. 2018 Jul 23;4(2):2055116918786598. doi: 10.1177/2055116918786598. eCollection 2018 Jul-Dec.

DOI:10.1177/2055116918786598
PMID:30057773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6058425/
Abstract

CASE SUMMARY

A 9-year-old male neutered Devon Rex cat presented with bilaterally symmetrical ulcerative lesions with mucopurulent exudate that developed rapidly. The lesions were apparent on the axillae, ventral abdomen and inguinal areas. The cat was systemically well. Piroxicam was being administered for palliative treatment of a previously diagnosed salivary adenocarcinoma. Histopathology revealed severe extensive epidermal ulceration with focal dyskeratotic keratinocytes in the stratum granulosum without lymphocyte satellitosis. Resolution of skin lesions was observed after discontinuing piroxicam. Similar lesions developed after previous piroxicam administration, further suggesting a possible adverse reaction to this drug. In addition, the Naranjo score indicated that piroxicam was a probable cause for the ulcerative skin lesions.

RELEVANCE AND NOVEL INFORMATION

This is the first report of piroxicam, a non-steroidal anti-inflammatory drug, as a probable cause of ulcerative skin lesions in a cat.

摘要

病例摘要

一只9岁已绝育的德文卷毛猫出现双侧对称的溃疡性病变，并伴有迅速发展的黏液脓性渗出物。病变出现在腋窝、腹侧腹部和腹股沟区域。这只猫全身状况良好。吡罗昔康正在用于对先前诊断的唾液腺癌进行姑息治疗。组织病理学显示严重广泛的表皮溃疡，颗粒层有局灶性角化不良的角质形成细胞，无淋巴细胞卫星现象。停用吡罗昔康后观察到皮肤病变消退。之前使用吡罗昔康后也曾出现类似病变，进一步提示可能对该药物有不良反应。此外，纳兰霍评分表明吡罗昔康可能是溃疡性皮肤病变的病因。

相关性及新信息

这是首次报道非甾体抗炎药吡罗昔康可能是猫溃疡性皮肤病变的病因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/2abb26588ca3/10.1177_2055116918786598-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/cbc9653045f2/10.1177_2055116918786598-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/2623017228d3/10.1177_2055116918786598-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/66170b2716a9/10.1177_2055116918786598-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/2d527a1471c1/10.1177_2055116918786598-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/2abb26588ca3/10.1177_2055116918786598-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/cbc9653045f2/10.1177_2055116918786598-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/2623017228d3/10.1177_2055116918786598-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/66170b2716a9/10.1177_2055116918786598-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/2d527a1471c1/10.1177_2055116918786598-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a335/6058425/2abb26588ca3/10.1177_2055116918786598-fig5.jpg

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本文引用的文献

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2
Hypersensitivity to Nonsteroidal Anti-inflammatory Drugs in Children and Adolescents: Cross-Intolerance Reactions.儿童和青少年对非甾体抗炎药的过敏反应：交叉不耐受反应。
J Investig Allergol Clin Immunol. 2015;25(4):259-69.
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Severe acute hepatitis induced by a DRESS syndrome to piroxicam.由对吡罗昔康的药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征诱发的严重急性肝炎。
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Clinical and microscopic characteristics of canine toxic epidermal necrolysis.犬中毒性表皮坏死松解症的临床和微观特征。
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Acute generalized exanthematous pustulosis induced by piroxicam: a case report.吡罗昔康诱发的急性泛发性脓疱性皮病：一例报告
Indian J Pharmacol. 2014 Mar-Apr;46(2):232-3. doi: 10.4103/0253-7613.129332.
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Occupationally induced fixed drug eruption caused by a non-steroidal anti-inflammatory agent.职业性非甾体抗炎药引起的固定性药疹
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Drug hypersensitivity reactions targeting the skin in dogs and cats.针对犬猫皮肤的药物过敏反应。
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