一种苯并噻唑衍生物在动物模型中对隐球菌病和念珠菌病的治疗显示出疗效。
A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models.
作者信息
Sá Nívea P, Lima Caroline M, A Dos Santos Julliana R, Costa Marliete C, de Barros Patrícia P, Junqueira Juliana C, Vaz Jéssica A, Oliveira Renata B, Fuchs Beth B, Mylonakis Eleftherios, Rosa Carlos A, Santos Daniel A, Johann Susana
机构信息
Department of Microbiology, Institute of Biological Sciences, Universidade Federal De Minas Gerais, Belo Horizonte, MG, Brazil.
Postgraduate Program, Universidade CEUMA (UNICEUMA), São Luís, MA, Brazil.
出版信息
Future Sci OA. 2018 Apr 25;4(6):FSO305. doi: 10.4155/fsoa-2018-0001. eCollection 2018 Jul.
AIM
In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against spp. and .
METHODS
The ability of CHT to act in biofilm and also to interfere with adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models.
RESULTS & CONCLUSION: In the present work we verified that CHT is found to inhibit and affecting biofilm in both and inhibited adhesion of to human buccal cells. When we evaluated , CHT prolonged survival of after infections with , or and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.
目的
在本研究中，我们测试了2-(2-(环己基亚甲基)肼基)-4-苯基噻唑（CHT）对[具体菌种1]和[具体菌种2]的作用。
方法
评估了CHT在生物膜中的作用能力以及对[某种物质]黏附的干扰情况，还评估了CHT在隐球菌病和念珠菌病无脊椎动物及小鼠模型中的疗效。
结果与结论
在本研究中，我们证实CHT可抑制[具体菌种1]和[具体菌种2]，影响生物膜形成，并抑制[具体菌种1]对人颊细胞的黏附。当我们评估[具体实验内容]时，CHT延长了感染[具体菌种3]、[具体菌种4]或[具体菌种5]后[实验对象]的存活时间，并使小鼠模型中器官的真菌负荷降低。这些结果证明了CHT的治疗潜力。
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