Department of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute , Milan , Italy.
Ophthalmology Service, Hospital de Clinicas "José de San Martín", Universidad de Buenos Aires , Buenos Aires , Argentina.
Ocul Immunol Inflamm. 2019;27(7):1090-1098. doi: 10.1080/09273948.2018.1501494. Epub 2018 Jul 30.
: To describe clinical features and outcome in bilateral acute retinal necrosis (BARN). : Observational retrospective longitudinal review of ocular findings. : Thirty eyes of 15 patients (age 44.1 ± 15.8). Delay of involvement between eyes was 57.2 ± 105.2 months (median 3, range 0.5-360). Herpes simplex virus (HSV)-1 was the most frequent (20 eyes, 66.6%), followed by HSV-2 (five eyes, 16.7%) and varicella zoster virus (VZV, four eyes, 13.3%). Visual acuity worsened in 7 (23%) eyes, improved in 4 (13%), and remained stable in 19 (63%). Major complications included retinal detachment (11 eyes, 36%), optic atrophy (11 eyes, 33%), proliferative vitreoretinopathy (four eyes, 13.3%), neovascular glaucoma (four eyes, 13.3%), phthisis bulbi (three eyes, 10%). Symptoms-to-referral average time was 2.7 ± 1.0 weeks (range 1-4). : In our study BARN was associated with severe visual outcome and high rate of ocular complications. Although BARN is a rare disease, the course is aggressive, regardless prompt referral in tertiary-care uveitis centers.
: 描述双侧急性视网膜坏死 (BARN) 的临床特征和结局。 : 对眼部发现进行观察性回顾性纵向研究。 : 15 例患者的 30 只眼（年龄 44.1 ± 15.8 岁）。双眼受累的时间间隔为 57.2 ± 105.2 个月（中位数为 3，范围为 0.5-360）。单纯疱疹病毒 (HSV)-1 是最常见的（20 只眼，66.6%），其次是 HSV-2（5 只眼，16.7%）和水痘带状疱疹病毒 (VZV，4 只眼，13.3%）。7 只眼（23%）视力恶化，4 只眼（13%）视力改善，19 只眼（63%）视力稳定。主要并发症包括视网膜脱离（11 只眼，36%）、视神经萎缩（11 只眼，33%）、增殖性玻璃体视网膜病变（4 只眼，13.3%）、新生血管性青光眼（4 只眼，13.3%）、眼球萎缩（3 只眼，10%）。症状到转诊的平均时间为 2.7 ± 1.0 周（范围 1-4）。 : 在我们的研究中，BARN 与严重的视力结果和高发生率的眼部并发症相关。尽管 BARN 是一种罕见疾病，但在三级护理葡萄膜炎中心及时转诊，病程仍具有侵袭性。
