Erben Vanessa, Bhardwaj Megha, Schrotz-King Petra, Brenner Hermann
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany.
Medical Faculty Heidelberg, Heidelberg University, 69120 Heidelberg, Germany.
Cancers (Basel). 2018 Jul 27;10(8):246. doi: 10.3390/cancers10080246.
Several approaches have been suggested to be useful in the early detection of colorectal neoplasms. Since metabolites are closely related to the phenotype and are available from different human bio-fluids, metabolomics are candidates for non-invasive early detection of colorectal neoplasms.
We aimed to summarize current knowledge on performance characteristics of metabolomics biomarkers that are potentially applicable in a screening setting for the early detection of colorectal neoplasms.
We conducted a systematic literature search in PubMed and Web of Science and searched for biomarkers for the early detection of colorectal neoplasms in easy-to-collect human bio-fluids. Information on study design and performance characteristics for diagnostic accuracy was extracted.
Finally, we included 41 studies in our analysis investigating biomarkers in different bio-fluids (blood, urine, and feces). Although single metabolites mostly had limited ability to distinguish people with and without colorectal neoplasms, promising results were reported for metabolite panels, especially amino acid panels in blood samples, as well as nucleosides in urine samples in several studies. However, validation of the results is limited.
Panels of metabolites consisting of amino acids in blood and nucleosides in urinary samples might be useful biomarkers for early detection of advanced colorectal neoplasms. However, to make metabolomic biomarkers clinically applicable, future research in larger studies and external validation of the results is required.
已有多种方法被认为对结直肠肿瘤的早期检测有用。由于代谢物与表型密切相关且可从不同人体生物流体中获取，代谢组学是结直肠肿瘤非侵入性早期检测的候选方法。
我们旨在总结目前关于代谢组学生物标志物性能特征的知识，这些标志物可能适用于结直肠肿瘤早期检测的筛查环境。
我们在PubMed和Web of Science上进行了系统的文献检索，并在易于收集的人体生物流体中寻找用于结直肠肿瘤早期检测的生物标志物。提取了有关研究设计和诊断准确性性能特征的信息。
最后，我们纳入了41项研究进行分析，这些研究调查了不同生物流体（血液、尿液和粪便）中的生物标志物。尽管单一代谢物大多区分结直肠肿瘤患者和非患者的能力有限，但在一些研究中，代谢物组合，尤其是血液样本中的氨基酸组合以及尿液样本中的核苷，报告了有前景的结果。然而，结果的验证有限。
由血液中的氨基酸和尿液样本中的核苷组成的代谢物组合可能是晚期结直肠肿瘤早期检测的有用生物标志物。然而，为使代谢组学生物标志物在临床上适用，需要在更大规模研究中进行进一步研究并对结果进行外部验证。
