在质膜上的功能拼接。
Functional patchworking at the plasma membrane.
机构信息
UMR 7592 Centre National de la Recherche Scientifique/Université Paris-Diderot, Institut Jacques Monod, Sorbonne Paris Cité, Paris, France.
Division of Cell Biology, Biocenter, Medical University of Innsbruck Austria, Innsbruck, Austria.
出版信息
EMBO J. 2018 Aug 15;37(16). doi: 10.15252/embj.2018100144. Epub 2018 Jul 30.
Abstract
Lipids and proteins are not evenly distributed within the plasma membrane (PM), but instead segregate laterally into many specialized microdomains whose functional relevance is not clear. In this issue, Busto (2018) demonstrate that substrate flux through a nutrient transporter drives the lateral relocation of the transporter between specific microdomains at the yeast PM, suggesting that regulating the lateral plasma membrane compartmentalization for individual proteins could be a general process for cellular response to environmental conditions.
摘要
脂质和蛋白质在质膜（PM）内不是均匀分布的，而是横向分隔成许多专门的微区，其功能相关性尚不清楚。在本期杂志中，Busto （2018）证明了通过营养转运体的底物通量驱动转运体在酵母 PM 中的特定微区之间的横向重定位，这表明调节单个蛋白质的质膜横向区室化可能是细胞对环境条件作出反应的一种普遍过程。
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