Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Yeast. 2010 Aug;27(8):473-8. doi: 10.1002/yea.1772.
The plasma membrane of Saccharomyces cerevisiae contains large microdomains enriched in ergosterol, which house at least nine integral proteins, including proton symporters. The domains adopt a characteristic structure of furrow-like invaginations typically seen in freeze-fracture pictures of fungal cells. Being stable for the time comparable with the cell cycle duration, they might be considered as fixed islands (rafts) in an otherwise fluid yeast plasma membrane. Rapidly moving endocytic marker proteins avoid the microdomains; the domain-accumulated proton symporters consequently show a reduced rate of substrate-induced endocytosis and turnover.
酿酒酵母的质膜含有富含麦角固醇的大微域，其中至少包含九个整合蛋白，包括质子转运体。这些域采用了在真菌细胞的冷冻断裂图像中常见的典型的沟状内陷结构。由于它们的稳定性与细胞周期持续时间相当，因此可以被认为是在通常处于流动状态的酵母质膜中的固定岛（筏）。快速移动的胞吞标记蛋白会避开这些微域；因此，积累在这些微域中的质子转运体表现出底物诱导的胞吞作用和周转率降低。
