Awis Qarni Fadil, Tai Evelyn, Wh Wan-Hazabbah, Husin Azlan
Ophthalmology, Universiti Sains Malaysia, Kubang Kerian, MYS.
Department of Ophthalmology, Universiti Sains Malaysia, Kubang Kerian, MYS.
Cureus. 2018 May 29;10(5):e2708. doi: 10.7759/cureus.2708.
Neurolymphomatosis is an atypical complication of non-Hodgkin lymphoma and leukaemia involving infiltration of neurotropic neoplastic cells in the central or peripheral nervous system. A 28-year-old Malay lady with background diffuse large B-cell lymphoma stage IV presented with left homonymous hemianopia associated with cognitive function deterioration. Her best corrected visual acuity was 6/9 in both eyes. Magnetic resonance imaging (MRI) of the brain showed a lesion suggestive of secondary lymphomatous infiltration of the splenium of corpus callosum. The patient underwent chemotherapy, after which repeated MRI showed a reduction in the lesion size. Homonymous hemianopia is a rare presentation of secondary central nervous system neurolymphomatosis. A comprehensive history, physical examination, and radiological imaging are essential to establish the diagnosis in patients presenting with visual field defects.
神经淋巴瘤病是非霍奇金淋巴瘤和白血病的一种非典型并发症，涉及亲神经肿瘤细胞浸润中枢或周围神经系统。一名28岁患有IV期弥漫性大B细胞淋巴瘤的马来女性，出现左侧同向性偏盲并伴有认知功能恶化。她双眼的最佳矫正视力均为6/9。脑部磁共振成像（MRI）显示有一个病变，提示胼胝体压部继发性淋巴瘤浸润。该患者接受了化疗，之后重复MRI显示病变大小减小。同向性偏盲是继发性中枢神经系统神经淋巴瘤病的一种罕见表现。对于出现视野缺损的患者，全面的病史、体格检查和影像学检查对于确立诊断至关重要。
