Uchida Daiki, Fujimoto Ayataka, Yamazoe Tomohiro, Yamamoto Takamichi, Enoki Hideo
Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
Epilepsy Behav Case Rep. 2018 Jan 10;10:14-17. doi: 10.1016/j.ebcr.2017.12.005. eCollection 2018.
A relationship between seizures and intracranial pressure (ICP) has been proposed, but not clearly identified. Whether changes in ICP can evoke seizures remains controversial. We report the case of a 23-year-old man who had undergone shunt surgery in childhood and later presented with focal impaired awareness seizures and behavior arrest. Seizures were uncontrolled despite 3 years of pharmacotherapy, but suddenly stopped after shunt removal. Our case supports the hypothesis that drug-resistant epilepsy can be influenced by changes in ICP. In particular, this case indicates that elevations in ICP may help reduce some seizures.
癫痫发作与颅内压（ICP）之间的关系已被提出，但尚未明确确定。颅内压的变化是否能引发癫痫发作仍存在争议。我们报告了一名23岁男性的病例，该患者童年时接受了分流手术，后来出现局灶性意识障碍性癫痫发作和行为停止。尽管进行了3年的药物治疗，癫痫发作仍无法控制，但在移除分流管后突然停止。我们的病例支持这样一种假设，即耐药性癫痫可能受颅内压变化的影响。特别是，该病例表明颅内压升高可能有助于减少一些癫痫发作。
