Tu Yingfeng, Sun Yao, Fan Yuhua, Cheng Zhen, Yu Bo
Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.
Cell Physiol Biochem. 2018;48(4):1401-1415. doi: 10.1159/000492251. Epub 2018 Jul 31.
Recently, multimodality molecular imaging has evolved into a fast-growing research field with goals of detecting and measuring biological processes in vivo non-invasively. Researchers have come to realize that the complementary abilities of different imaging modalities over single modality could provide more precisely information for the diagnosis of diseases. At present, nanoparticles-based multimodal imaging probes have received significant attention because of their ease of preparation and straightforward integration of each modality into one entity. More importantly, nanotechnology has an increasing impact on multimodality molecular imaging of cardiovascular diseases, such as atherosclerosis and vulnerable plaque, myocardial infarction, angiogenesis, apoptosis and so on. In this review, we briefly summarize that various nanoprobes are exploited for targeted molecular imaging of cardiovascular diseases, as well as associated multimodality imaging approaches and their applications in the diagnosis and treatment of cardiovascular diseases.
近年来，多模态分子成像已发展成为一个快速发展的研究领域，其目标是在体内非侵入性地检测和测量生物过程。研究人员已经意识到，不同成像模态相对于单一模态的互补能力可以为疾病诊断提供更精确的信息。目前，基于纳米颗粒的多模态成像探针因其易于制备且能将每种模态直接整合到一个实体中而受到广泛关注。更重要的是，纳米技术对心血管疾病的多模态分子成像的影响日益增加，如动脉粥样硬化和易损斑块、心肌梗死、血管生成、细胞凋亡等。在本综述中，我们简要总结了各种纳米探针用于心血管疾病的靶向分子成像，以及相关的多模态成像方法及其在心血管疾病诊断和治疗中的应用。
