磁粒子成像：当前和未来的应用，磁性纳米粒子的合成方法和安全措施。

College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.

Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, USA.

Int J Mol Sci. 2021 Jul 17;22(14):7651. doi: 10.3390/ijms22147651.

Magnetic nanoparticles (MNPs) have a wide range of applications; an area of particular interest is magnetic particle imaging (MPI). MPI is an imaging modality that utilizes superparamagnetic iron oxide particles (SPIONs) as tracer particles to produce highly sensitive and specific images in a broad range of applications, including cardiovascular, neuroimaging, tumor imaging, magnetic hyperthermia and cellular tracking. While there are hurdles to overcome, including accessibility of products, and an understanding of safety and toxicity profiles, MPI has the potential to revolutionize research and clinical biomedical imaging. This review will explore a brief history of MPI, MNP synthesis methods, current and future applications, and safety concerns associated with this newly emerging imaging modality.

磁性纳米粒子（MNPs）有广泛的应用；一个特别感兴趣的领域是磁性粒子成像（MPI）。MPI 是一种成像方式，利用超顺磁氧化铁粒子（SPIONs）作为示踪粒子，在广泛的应用中产生高灵敏度和特异性的图像，包括心血管、神经成像、肿瘤成像、磁热疗和细胞跟踪。尽管存在一些需要克服的障碍，包括产品的可及性以及对安全性和毒性特征的理解，但 MPI 有可能彻底改变研究和临床生物医学成像。本文将探讨 MPI 的简要历史、MNP 的合成方法、当前和未来的应用以及与这种新兴成像方式相关的安全问题。