Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, 213003, Jiangsu, China.
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, 213003, Jiangsu, China.
J Hematol Oncol. 2018 Jul 31;11(1):98. doi: 10.1186/s13045-018-0643-z.
Circular RNA (circRNA) is a new type of endogenous non-coding RNAs (ncRNAs). circRNA regulates gene expression in many biological processes, and it also participates in the initiation and development of various diseases, including tumors, which are the focus of present research. With the development of high-throughput sequencing technique, an increasing number of circRNAs closely related to tumors have been discovered. According to numerous studies, there is a significant difference in the expressions of circRNAs among a variety of tumor tissues and para-carcinoma normal tissues. Some specifically expressed circRNAs may potentially serve as new biomarkers for tumor diagnosis and prognosis. This systemic review briefly introduces the characteristics, biogenesis, and functions of circRNAs, as well as discusses their relationship with cancer in detail. In addition, this article also describes several research strategies for circRNAs.
环状 RNA (circRNA) 是一种新型的内源性非编码 RNA (ncRNA)。circRNA 在许多生物过程中调节基因表达，并且它还参与各种疾病的发生和发展，包括肿瘤，这是当前研究的重点。随着高通量测序技术的发展，越来越多与肿瘤密切相关的 circRNA 被发现。根据大量研究，在各种肿瘤组织和癌旁正常组织中，circRNA 的表达存在显著差异。一些特异性表达的 circRNA 可能潜在地作为肿瘤诊断和预后的新生物标志物。本系统综述简要介绍了 circRNA 的特征、生物发生和功能，并详细讨论了它们与癌症的关系。此外，本文还描述了几种 circRNA 的研究策略。
