Eastwood M A, Elton R A, Smith J H
Am J Clin Nutr. 1986 Mar;43(3):343-9. doi: 10.1093/ajcn/43.3.343.
Stool weight, fecal constituents, bile acids, fat, neutral sterols, and intestinal transit time were recorded in 28 subjects over 18 mo. During the first 12 mo the subjects ate white bread. They were studied for an initial period of 7 days, and after 6 mo (study period 1). For the first 6 mo they ate their usual intake of bread, they then increased their white bread intake by 62 g/day for 6 mo (study period 2). The subjects ate a self-selected diet throughout the 18 mo study. During the last 6 mo (study period 3) the subjects replaced white bread by the same amount of wholemeal bread as in study period 2. No increase in stool weight occurred until study period 3 when there was an increase of 20%. There developed a linear relationship between stool weight and intestinal transit time which was not found during the initial first and second study periods. A seasonal influence on serum cholesterol was not observed during the wholemeal bread period. Fecal bile acid excretion was unchanged throughout the experiment.
对28名受试者进行了18个月的观察，记录了他们的粪便重量、粪便成分、胆汁酸、脂肪、中性固醇和肠道转运时间。在最初的12个月里，受试者食用白面包。他们在最初的7天以及6个月后（研究期1）接受研究。在最初的6个月里，他们按平常的摄入量食用面包，然后在接下来的6个月里（研究期2），将白面包的摄入量增加62克/天。在整个18个月的研究期间，受试者采用自选饮食。在最后6个月（研究期3），受试者将白面包换成与研究期2相同量的全麦面包。直到研究期3粪便重量才增加，增加了20%。粪便重量与肠道转运时间之间形成了线性关系，而在最初的第一和第二研究期未发现这种关系。在食用全麦面包期间未观察到血清胆固醇受季节影响。整个实验过程中粪便胆汁酸排泄没有变化。
