Jun Ji-Young, Park Ji-Hye, Youn Choon Shik, Lee Jong Hee
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Yemiwon Dermatologic Clinic, Seoul, Korea.
Ann Dermatol. 2018 Aug;30(4):458-461. doi: 10.5021/ad.2018.30.4.458. Epub 2018 Jun 28.
Intramuscular injection of botulinum toxin A (BTXA) is commonly used for the treatment of forehead wrinkles. In practice, physicians often use an intradermal injection for this purpose, as they feel that there is a lower risk of adverse effects compared with intramuscular injection. However, there are no direct comparative studies between those two injection modalities. We conducted a 24-week long, double-blinded, split-face, pilot study of three participants to compare the efficacy and safety of intradermal or intramuscular injection of BTXA for the treatment of forehead wrinkles. Maximum improvement of wrinkles and the time to achieve maximum effect were similar for both methods. The brow level was lower on the intramuscular injection side throughout the follow-up period for all participants. Subjective satisfaction with wrinkles was similar on both sides, but patients felt more heaviness of the eyebrow on the intramuscular side. No serious side effects were noted. In conclusion, the anti-wrinkle effect of BTXA was not significantly different between intramuscular and intradermal injections. However, side effects such as eyebrow ptosis, and heaviness were more prominent after intramuscular injection.
肌肉注射A型肉毒毒素（BTXA）常用于治疗额部皱纹。在实际操作中，医生常为此采用皮内注射，因为他们认为与肌肉注射相比，皮内注射产生不良反应的风险更低。然而，这两种注射方式之间尚无直接的对比研究。我们对三名参与者进行了一项为期24周的双盲、半脸对照的前瞻性研究，以比较皮内或肌肉注射BTXA治疗额部皱纹的疗效和安全性。两种方法在皱纹的最大改善程度和达到最大效果的时间方面相似。在整个随访期间，所有参与者肌肉注射一侧的眉水平较低。两侧对皱纹的主观满意度相似，但患者感觉肌肉注射侧的眉毛更沉重。未观察到严重的副作用。总之，肌肉注射和皮内注射BTXA的抗皱效果无显著差异。然而，肌肉注射后眉毛下垂和沉重等副作用更为明显。
