Department of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Department of Abdominal Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, China.
Acad Radiol. 2022 Dec;29(12):1842-1851. doi: 10.1016/j.acra.2022.03.009. Epub 2022 Apr 5.
To assess the diagnostic performance of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and fluorine-18-fluorodeoxyglucose (F-FDG) positron-emission tomography/computed tomography (PET/CT) parameters in evaluating the biological behavior of soft tissue tumors.
We retrospectively analyzed DCE-MRI and F-FDG PET/CT parameters in 78 patients with pathology-confirmed soft tissue tumors. A total of 78 patients had undergone DCE-MRI examination, while 24 patients with malignant soft tissue tumor had undergone F-FDG PET/CT examination. Microvessel density (MVD) and the Ki-67 labeling index (LI) were detected using immunohistochemistry. Differences in parameters (Ktrans, Kep, Ve, MVD, and Ki-67 LI) between benign and malignant tumors were compared. Differences in parameters (Ktrans, Kep, Ve, MVD, and SUV) between high- and low-proliferation malignant tumors (grouped by Ki-67 LI) were compared. Correlation of the DCE-MRI and F-FDG PET/CT parameters with MVD and Ki-67 LI was analyzed.
Only the Ktrans, Kep, MVD, and Ki-67 LI differed significantly between the benign and malignant soft tissue tumors (all p < 0.001). Only Kep (p = 0.033) and SUV (p = 0.001) differed significantly between high- and low-proliferation malignant soft tissue tumors. Ktrans, Kep, and SUV correlated positively with MVD (r = 0.805, 0.778, 0.730, respectively; all p < 0.001), and with Ki-67 LI (r = 0.721, 0.685, 0.655, respectively; all p < 0.001).
DCE-MRI and F-FDG PET/CT parameters indicate soft tissue tumor biological behavior and can be used to differentiate between benign and malignant soft tissue tumors and between high- and low-proliferation malignant soft tissue tumors.
评估动态对比增强磁共振成像（DCE-MRI）和氟-18-氟代脱氧葡萄糖（F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）参数在评估软组织肿瘤生物学行为中的诊断性能。
我们回顾性分析了 78 例经病理证实的软组织肿瘤患者的 DCE-MRI 和 F-FDG PET/CT 参数。78 例患者均行 DCE-MRI 检查，24 例恶性软组织肿瘤患者行 F-FDG PET/CT 检查。采用免疫组织化学法检测微血管密度（MVD）和 Ki-67 标记指数（LI）。比较良、恶性肿瘤间各参数（Ktrans、Kep、Ve、MVD 和 Ki-67 LI）的差异。比较高、低增殖恶性肿瘤（按 Ki-67 LI 分组）间各参数（Ktrans、Kep、Ve、MVD 和 SUV）的差异。分析 DCE-MRI 和 F-FDG PET/CT 参数与 MVD 和 Ki-67 LI 的相关性。
仅良性和恶性软组织肿瘤间 Ktrans、Kep、MVD 和 Ki-67 LI 差异有统计学意义（均 p<0.001）。仅 Kep（p=0.033）和 SUV（p=0.001）在高、低增殖恶性软组织肿瘤间差异有统计学意义。Ktrans、Kep 和 SUV 与 MVD 呈正相关（r=0.805、0.778、0.730，均 p<0.001），与 Ki-67 LI 亦呈正相关（r=0.721、0.685、0.655，均 p<0.001）。
DCE-MRI 和 F-FDG PET/CT 参数可反映软组织肿瘤生物学行为，有助于鉴别良、恶性软组织肿瘤和高、低增殖恶性软组织肿瘤。
