Anik Ilhan Gokce, Kanlioglu Cansu, Arslan Gaye, Yildizhan Begum, Pekin Tanju
Department of Obstetrics and Gynecology, Marmara University, Istanbul, Turkey.
Arch Gynecol Obstet. 2018 Oct;298(4):821-825. doi: 10.1007/s00404-018-4862-x. Epub 2018 Aug 1.
This study aimed at evaluating galectin-3 levels as a novel metabolic biomarker in women with PCOS.
Ninety consecutive women with PCOS fulfilling the inclusion criteria were divided into two groups according to the presence of metabolic syndrome as MetS+ and MetS-. Clinical, hormonal, and metabolic parameters and galectin-3 levels were compared between the groups. Correlation analyses were performed between galectin-3 and clinical and metabolic parameters.
Ninety PCOS subjects were enrolled in the study, 25 of which were diagnosed with MetS. Waist-to-hip ratio, systolic and diastolic blood pressures, triglyceride, HOMA-IR, FAI, FGS, and galectin-3 levels were significantly higher in the MetS+ group compared with the MetS- group (13.19 ± 5.63 vs 9.37 ± 3.99 ng/mL, respectively, p = 0.001). HDL cholesterol was significantly higher in the MetS- group than in the MetS+ one. Galectin-3 levels were found to be positively correlated with systolic blood pressure (r = 0.450, p < 0.01), diastolic blood pressure (r = 0.293, p < 0.01), and triglyceride levels (r = 0.218, p < 0.05) in women with PCOS.
Galectin-3 may be a promising novel biomarker in women with PCOS. Galectin-3 levels were significantly higher in the MetS+ group compared with the MetS- one and positively correlated with systolic, diastolic blood pressures and triglyceride levels in women with PCOS.
本研究旨在评估半乳糖凝集素-3水平作为多囊卵巢综合征（PCOS）女性一种新型代谢生物标志物的情况。
90例符合纳入标准的连续PCOS女性患者，根据是否存在代谢综合征分为MetS+组和MetS-组。比较两组的临床、激素和代谢参数以及半乳糖凝集素-3水平。对半乳糖凝集素-3与临床和代谢参数进行相关性分析。
90例PCOS受试者纳入研究，其中25例被诊断为代谢综合征。与MetS-组相比，MetS+组的腰臀比、收缩压和舒张压、甘油三酯、稳态模型评估的胰岛素抵抗指数（HOMA-IR）、游离雄激素指数（FAI）、空腹血糖（FGS）和半乳糖凝集素-3水平显著更高（分别为13.19±5.63 vs 9.37±3.99 ng/mL，p = 0.001）。MetS-组的高密度脂蛋白胆固醇显著高于MetS+组。发现PCOS女性的半乳糖凝集素-3水平与收缩压（r = 0.450，p < 0.01）、舒张压（r = 0.293，p < 0.01）和甘油三酯水平（r = 0.218，p < 0.05）呈正相关。
半乳糖凝集素-3可能是PCOS女性一种有前景的新型生物标志物。与MetS-组相比，MetS+组的半乳糖凝集素-3水平显著更高，且与PCOS女性的收缩压、舒张压和甘油三酯水平呈正相关。
