Schill W B
Fortschr Med. 1977 Mar 24;95(12):790-2.
The trypsin-like enzyme acrosin has a key function in the fertilization process enabling penetration of the zona pellucida of the ovum by the spermatozoa. Under experimental conditions acrosin inhibitors are able to prevent fertilization. In the male genital tract high amounts of low molecular weight acid-stable proteinase inhibitors are found having mainly protective functions, but may play also a significant role in the process of capacitation. Aside from biochemical and physiological investigations the presented studies are a contribution towards the clinical applicability of the acrosin-inhibitor system with special respect to its diagnostic and prognostic value for andrology. In addition, inhibition of acrosin may be an approach for an effective contraceptive method.
类胰蛋白酶顶体酶在受精过程中具有关键作用，能使精子穿透卵子的透明带。在实验条件下，顶体酶抑制剂能够阻止受精。在男性生殖道中发现了大量低分子量的酸稳定蛋白酶抑制剂，它们主要起保护作用，但在精子获能过程中也可能发挥重要作用。除了生化和生理学研究外，本研究还为顶体酶抑制剂系统在临床上的应用做出了贡献，特别是其在男科学中的诊断和预后价值。此外，抑制顶体酶可能是一种有效的避孕方法。
