Child Trends, Bethesda, MD, and Columbia University, New York.
New York University Langone Medical Center, New York; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY.
J Am Acad Child Adolesc Psychiatry. 2018 Aug;57(8):571-582.e1. doi: 10.1016/j.jaac.2018.04.015. Epub 2018 Jun 18.
Little is known of the factors that influence the course of childhood attention-deficit/hyperactivity disorder (ADHD). Objectives were to identify early features predictive of the adult outcome of children with ADHD. In the longest prospective follow-up to date of children with ADHD, predictors of multiple functional domains were examined: social, occupational, and overall adjustment and educational and occupational attainment.
White boys (6-12 years, mean age 8 years) with ADHD (N = 135), selected to be free of conduct disorder, were assessed longitudinally through adulthood (mean age 41) by clinicians blinded to all previous characteristics. Predictors had been recorded in childhood and adolescence (mean age 18).
Childhood IQ was positively associated with several outcomes: educational attainment, occupational rank, and social and occupational adjustment. Despite their low severity, conduct problems in childhood were negatively related to overall function, educational attainment, and occupational functioning. Two other childhood features that had positive associations with adult adjustment were socioeconomic status and reading ability, which predicted educational attainment. Of multiple adolescent characteristics, 4 were significant predictors: antisocial behaviors predicted poorer educational attainment; educational goals were related to better overall function; early job functioning had a positive relation with social functioning; and early social functioning was positively related to occupational functioning.
Other than childhood IQ, which predicted better outcomes in several domains, there were no consistent prognosticators of adult function among children with ADHD. Providing additional supports to children with relatively lower IQ might improve the adult functional outcome of children with ADHD. However, predicting the course of children with ADHD remains a challenge.
对于影响儿童注意缺陷多动障碍(ADHD)病程的因素知之甚少。目的是确定可预测 ADHD 儿童成年结局的早期特征。在对 ADHD 儿童进行的迄今为止最长的前瞻性随访中,检查了多个功能领域的预测因素:社会、职业和整体适应情况以及教育和职业成就。
选择无品行障碍的白人男孩(6-12 岁,平均年龄 8 岁)进行 ADHD 研究,通过临床医生对所有既往特征进行盲法评估,一直随访到成年(平均年龄 41 岁)。预测因子在儿童期和青春期(平均年龄 18 岁)就已经记录下来。
儿童期智商与多个结果呈正相关:教育程度、职业等级以及社会和职业适应情况。尽管 ADHD 儿童的严重程度较低,但童年期的品行问题与整体功能、教育程度和职业功能呈负相关。与成年适应情况呈正相关的另外两个儿童期特征是社会经济地位和阅读能力,它们预测了教育程度。在多种青少年特征中,有 4 个是显著的预测因素:反社会行为预测较差的教育程度;教育目标与整体功能较好相关;早期工作功能与社会功能呈正相关;早期社会功能与职业功能呈正相关。
除了预测多个领域结果较好的儿童期智商外,对于 ADHD 儿童,没有一致的成年功能预后预测因子。为智商相对较低的儿童提供额外支持可能会改善 ADHD 儿童的成年功能结局。然而,预测 ADHD 儿童的病程仍然是一个挑战。