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脑肿瘤的流行病学。

Epidemiology of Brain Tumors.

机构信息

Brain Tumor Research, Case Comprehensive Cancer Center, Institute for Computational Biology, Case Western Reserve University School of Medicine, 2-526 Wolstein Research Building, 103 Cornell Road, Cleveland, OH 44106-7295, USA.

Department of Medicine, Section of Epidemiology and Population Sciences, Dan Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3498, USA.

出版信息

Neurol Clin. 2018 Aug;36(3):395-419. doi: 10.1016/j.ncl.2018.04.001. Epub 2018 Jun 15.

Abstract

Incidence, prevalence, and survival for brain tumors varies by histologic type, age at diagnosis, sex, and race/ethnicity. Significant progress has been made in identifying potential risk factors for brain tumors, although more research is warranted. The strongest risk factors that have been identified thus far include allergies/atopic disease, ionizing radiation, and heritable genetic factors. Further analysis of large, multicenter, epidemiologic studies, as well as well annotated omic datasets (including genomic, epigenomic, transcriptomic, proteomic, or metabolomics data) can potentially lead to further understanding of the relationship between gene and environment in the process of brain tumor development.

摘要

脑肿瘤的发病率、患病率和生存率因组织学类型、诊断时的年龄、性别和种族/民族而异。虽然还需要更多的研究,但在确定脑肿瘤的潜在风险因素方面已经取得了重大进展。迄今为止,已确定的最强风险因素包括过敏/特应性疾病、电离辐射和遗传性遗传因素。对大型、多中心的流行病学研究以及注释良好的组学数据集(包括基因组、表观基因组、转录组、蛋白质组或代谢组学数据)的进一步分析,可能有助于进一步了解脑肿瘤发展过程中基因与环境之间的关系。

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