MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, 101 College Street, 14-601, Toronto, Ontario M5G 1L7, Canada.
MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, 101 College Street, 14-601, Toronto, Ontario M5G 1L7, Canada.
Neurol Clin. 2018 Aug;36(3):439-447. doi: 10.1016/j.ncl.2018.04.003.
The recent update of the World Health Organization (WHO) classification of tumors of the central nervous system represents a paradigm shift. Previous iterations of the classification relied on morphologic features for classification. In the 2016 update, the definitions of specific neoplastic entities tumors now include precise molecularly defined entities. This article discusses this paradigm shift, and focuses on the refinements in classification criteria, relations to previous editions, and their implication to neuropathology and neuro-oncology practice. The authors distinguish the criteria that were used to determine why molecular changes were included.
世界卫生组织（WHO）中枢神经系统肿瘤分类的最新更新代表了一种范式转变。之前的分类版本依赖于形态学特征进行分类。在 2016 年的更新中，特定肿瘤实体的定义现在包括精确的分子定义实体。本文讨论了这种范式转变，并重点介绍了分类标准的细化、与以前版本的关系以及它们对神经病理学和神经肿瘤学实践的影响。作者区分了用于确定为何纳入分子变化的标准。
