Katsushima Keisuke, Joshi Kandarp, Perera Ranjan J
Department of Neurosurgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, Florida, USA.
Neurooncol Adv. 2023 Jun 13;5(1):vdad063. doi: 10.1093/noajnl/vdad063. eCollection 2023 Jan-Dec.
Circular RNAs (circRNAs) are a class of RNA with a stable cyclic structure. They are expressed in various tissues and cells with conserved, specific characteristics. CircRNAs have been found to play critical roles in a wide range of cellular processes by regulating gene expression at the epigenetic, transcriptional, and posttranscriptional levels. There is an accumulation of evidence on newly discovered circRNAs, their molecular interactions, and their roles in the development and progression of human brain tumors, including cell proliferation, cell apoptosis, invasion, and chemoresistance. Here we summarize the current state of knowledge of the circRNAs that have been implicated in brain tumor pathogenesis, particularly in gliomas and medulloblastomas. In providing a comprehensive overview of circRNA studies, we highlight how different circRNAs have oncogenic or tumor-suppressive roles in brain tumors, making them attractive therapeutic targets and biomarkers for personalized therapy and precision diagnostics. This review article discusses circRNAs' functional roles and the prospect of using them as diagnostic biomarkers and therapeutic targets in patients with brain tumors.
环状RNA（circRNAs）是一类具有稳定环状结构的RNA。它们在各种组织和细胞中表达，具有保守的特定特征。已发现circRNAs通过在表观遗传、转录和转录后水平上调节基因表达，在广泛的细胞过程中发挥关键作用。关于新发现的circRNAs、它们的分子相互作用以及它们在人类脑肿瘤发生发展中的作用，包括细胞增殖、细胞凋亡、侵袭和化疗耐药性，有越来越多的证据积累。在这里，我们总结了与脑肿瘤发病机制相关的circRNAs的当前知识状态，特别是在神经胶质瘤和髓母细胞瘤中的情况。在全面概述circRNA研究时，我们强调了不同的circRNAs如何在脑肿瘤中发挥致癌或肿瘤抑制作用，使其成为个性化治疗和精准诊断中有吸引力的治疗靶点和生物标志物。这篇综述文章讨论了circRNAs的功能作用以及将它们用作脑肿瘤患者诊断生物标志物和治疗靶点的前景。
